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Determination of some cathinones, tropane alkaloids, and “pharmaceutical narcotics” in urine

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Abstract

A procedure is proposed for determining some narcotic and psychoactive substances (cathinones, tropane alkaloids, derivatives of ?-aminobutyric acid) in urine, including sample preparation and the determination of analytes by HPLC coupled with electrospray ionization tandem mass spectrometry. Sample preparation involved acid hydrolysis or the dilution of the sample. The lower limit of quantification is 200 pg/mL; the limit of detection is 100 pg/mL; and the calibration curves are linear in the range 0.2–50 ng/mL. The procedure was tested on real samples provided by the Toxicological Department of the Krasnodar Regional Narcological Dispensary. The high sensitivity of the analytical system ensures its use for the determination of narcotic preparations within a certain time after their intake, which may be of particular importance for forensic examinations.

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Authors and Affiliations

  1. Kuban State University, Stavropol’skaya ul. 149, Krasnodar, 350040, Russia

    A. A. Azaryan & A. Z. Temerdashev

  2. Narcological Dispensary, Ministry of Health of the Krasnodar Krai, ul. Tyulyaeva 10, Krasnodar, 350080, Russia

    E. V. Svetlichnaya

  3. Regional Administration of the Federal Service for Drug Control in Krasnodar Krai, ul. Lenina 88, Krasnodar, 350033, Russia

    A. G. Kal’nitskii

  4. Main Administration of the Ministry of Internal Affairs in Krasnodar Krai, ul. Gavrilova 96, Krasnodar, 350020, Russia

    I. A. Balabaev

Authors
  1. A. A. Azaryan
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  2. A. Z. Temerdashev
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  3. E. V. Svetlichnaya
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  4. A. G. Kal’nitskii
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  5. I. A. Balabaev
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Corresponding author

Correspondence to A. Z. Temerdashev.

Additional information

Original Russian Text © A.A. Azaryan, A.Z. Temerdashev, E.V. Svetlichnaya, A.G. Kal’nitskii, I.A. Balabaev, 2016, published in Zhurnal Analiticheskoi Khimii, 2016, Vol. 71, No. 9, pp. 995–1004.

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Azaryan, A.A., Temerdashev, A.Z., Svetlichnaya, E.V. et al. Determination of some cathinones, tropane alkaloids, and “pharmaceutical narcotics” in urine. J Anal Chem 71, 955–964 (2016). https://doi.org/10.1134/S1061934816090021

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  • DOI: https://doi.org/10.1134/S1061934816090021

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