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Optical biopsy of breast cancer tissue

  • Laser Methods in Chemistry, Biology, and Medicine
  • Published:
Laser Physics

Abstract

In this paper, we report results of Fluorescence Emission Spectra (FES) and Stokes Shift Spectra (SSS) of 19 cancer tissue of invasive ductal carcinoma of different grades in comparison with normal breast tissues (obtained away from tumor regions). We were able to get distinct differences in the spectral features of normal and malignant tissues in terms of the ratios of concentrations of biomolecules like tryptophan, collagen and NADH. The sensitivity and specificity were in the range of 75%. What was all the more important was the parallelism in the spectral features of normal and malignant breast tissue pieces of above set of subjects. The objective of our research is to evolve one such protocol and the first step is the spectral characterization of in vitro optical analyses of excised tumor tissues.

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Authors and Affiliations

  1. Research Chair on Laser Diagnosis of Cancers, King Saud University, Riyadh, KSA

    M. S. AlSalhi, S. Devanesan, M. Atif & V. Masilamani

  2. King Faisal Research Centre, King Faisal Hospital Riyadh, Riyadh, KSA

    S. Ben Amer

  3. Princess Johara Al-Ibrahim Research Centre for Prostate Cancer, College of Medicine, King Khalid University Hospital, King Saud University Riyadh, Riyadh, KSA

    K. Farhat & D. Rabah

  4. Department of Physics and Astronomy, King Saud University, College of Science, Riyadh, KSA

    M. S. AlSalhi

  5. Department of Physics and Astronomy, Dammam University, College of Science, Al-Khobar, KSA

    M. Atif & Reem. K. S. Al-Dakheel

Authors
  1. M. S. AlSalhi
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  2. S. Ben Amer
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  3. K. Farhat
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  4. D. Rabah
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  5. S. Devanesan
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  6. M. Atif
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  7. V. Masilamani
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  8. Reem. K. S. Al-Dakheel
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Corresponding author

Correspondence to M. S. AlSalhi.

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Original Text © Astro, Ltd., 2012.

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AlSalhi, M.S., Ben Amer, S., Farhat, K. et al. Optical biopsy of breast cancer tissue. Laser Phys. 22, 1358–1363 (2012). https://doi.org/10.1134/S1054660X12080014

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  • DOI: https://doi.org/10.1134/S1054660X12080014

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