Skip to main content
Log in

Sporadic Versus Hereditary forms of Colorectal Cancer with the DNA Microsatellite Instability Phenotype: to ‘lump’ or ‘Split’?

  • Published:
Familial Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Yamashita K, Dai T, Dai Y et al. Genetics supersedes epigenetics in colon cancer phenotype. Cancer Cell 2003; 4: 121–31.

    Google Scholar 

  2. Gazzoli I, Loda M, Garber J et al. A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the hMLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res 2002; 62: 3925–8.

    Google Scholar 

  3. Miyakura Y, Sugano K, Akasu T et al. Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancer with microsatellite instability. Clin Gastroenterol Hepatol 2004; 2: 147–56.

    Google Scholar 

  4. Suter CM, D.I.K. Xu M, Ward RL. Germline epimutation of MLH1 in individuals with multiple cancers. Nat Gen 2004; 36: 497–501.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jass, J.R. Sporadic Versus Hereditary forms of Colorectal Cancer with the DNA Microsatellite Instability Phenotype: to ‘lump’ or ‘Split’?. Familial Cancer 3, 83 (2004). https://doi.org/10.1023/B:FAME.0000039914.01969.df

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:FAME.0000039914.01969.df

Keywords

Navigation