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Selective Regulation of Acid, Pepsinogen, and Bicarbonate Secretion in the Stomach by Different C-Fiber Populations of Vagus Nerve

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Abstract

Acute experiments on anesthetized rats showed that group B nerve fibers of the subphrenic portion of the vagus nerve do not participate in the regulation of gastric secretion. Gastric acid production is mainly controlled by fast C-fibers (2.11±0.09 m/sec), while secretion of pepsinogen and bicarbonates depends on activity of both fast and slow (0.95±0.11 m/sec) C-fibers. Some fast conduction C-fibers stimulating the release of bicarbonates in the stomach are capsaicin-sensitive afferents. The local effect of these afferents depends on cholinergic transmission and most probably it is mediated via its modulation.

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REFERENCES

  1. V. A. Zolotarev, S. A. Polenov, G. P. Lepnev, et al., Ros.Fiziol. Zh., 82, No. 7, 111–116 (1996).

    Google Scholar 

  2. R. P. Khropycheva, V. A. Zolotarev, and S. A. Polenov, Ibid., 86, No. 11, 1539–1547 (2000).

    Google Scholar 

  3. H. R. Berthoud and T. L. Powley, J. Comp. Neurol., 319, 261–272 (1992).

    Google Scholar 

  4. H. R. Berthoud, L. M. Patterson, A. E. Willing, et al., Brain Res., 746, 195–206 (1997).

    Google Scholar 

  5. H. R. Berthoud and T. L. Powley, J. Auton. Nerv. Syst., 19, No. 1, 77–84 (1987).

    Google Scholar 

  6. L. A. Blackshaw, A. J. Page, and E. R. Partosoedarso, Neuroscience, 96, 407–416 (2000).

    Google Scholar 

  7. K. Guttu, B. Rosok, H. Gislason, et al., Scand. J. Gastroenterol., 26, 431–441 (1991).

    Google Scholar 

  8. M. C. Holst, J. B. Kelly, and T. L. Powley, J. Comp. Neurol., 381, No. 1, 81–100 (1997).

    Google Scholar 

  9. P. Holzer, Gastroenterology, 114, 823–839 (1998).

    Google Scholar 

  10. L. Mitchell and M. D. Schubert, Curr. Opin. Gastroenterol., 16, 463–468 (2000).

    Google Scholar 

  11. J. C. Pretchl and T. L. Powley, Anat. Embryol., 181, 101–115 (1990).

    Google Scholar 

  12. B. Qian, A. Danielsson, and M. El-Salhy, Scand. J. Gastroenterol., 31, 529–540 (1996).

    Google Scholar 

  13. K. A. Sharkey, L. D. Oland, D. R. Kirk, et al., Br. J. Pharmacol., 103, No. 4, 1997–dy2003 (1991).

    Google Scholar 

  14. P. J. Waddel and S. N. Lawson, Pain, 39, 237–242 (1989).

    Google Scholar 

  15. H. Zheng and H. R. Berthoud, Am. J. Physiol., 279, G1073–G1081 (2000).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Digestion Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    V. A. Zolotarev, R. P. Khropycheva & S. A. Polenov

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  1. V. A. Zolotarev
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  2. R. P. Khropycheva
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  3. S. A. Polenov
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Correspondence to V. A. Zolotarev.

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Zolotarev, V.A., Khropycheva, R.P. & Polenov, S.A. Selective Regulation of Acid, Pepsinogen, and Bicarbonate Secretion in the Stomach by Different C-Fiber Populations of Vagus Nerve. Bulletin of Experimental Biology and Medicine 133, 210–213 (2002). https://doi.org/10.1023/A:1015810011726

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