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Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats

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Abstract

Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract. The most pronounced activation of enzymes was observed in 11-month-old animals. This effect diminished the differences in enzyme activities between young and old rats (compared to untreated animals). Our results indicate that Epithalon modulates activity of gastrointestinal enzymes during aging.

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Authors and Affiliations

  1. St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Russia

    V. Kh. Khavinson, V. V. Malinin, N. M. Timofeeva, V. V. Egorova & A. A. Nikitina

  2. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. Kh. Khavinson, V. V. Malinin, N. M. Timofeeva, V. V. Egorova & A. A. Nikitina

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  1. V. Kh. Khavinson
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  2. V. V. Malinin
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  3. N. M. Timofeeva
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  4. V. V. Egorova
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  5. A. A. Nikitina
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Correspondence to V. Kh. Khavinson.

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Khavinson, V.K., Malinin, V.V., Timofeeva, N.M. et al. Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats. Bulletin of Experimental Biology and Medicine 133, 290–292 (2002). https://doi.org/10.1023/A:1015807305791

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  • DOI: https://doi.org/10.1023/A:1015807305791

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