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Hemangioblastomas and Other Uncommon Intramedullary Tumors

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Abstract

Astrocytoma and ependymoma make up 90% of intramedullary tumors between them. However, a host of less common tumors form the remaining 10%: these include hemangioblastomas, subependymomas, gangliogliomas and other neuronal variants, metastases from extraneural cancers, and a host of other lesions that typically occur intracranially but which present on rare occasions in the intramedullary location. Most neurosurgeons will encounter the unusual tumors of the spinal cord described in this review only a few times during their professional careers, but it is nevertheless important to recognize the distinct radiological and intraoperative features of those for which significant series of patients have been accumulated. Metastases and germinomas aside, the other neoplasms described here are relatively benign in their clinical and histological behavior, and can be meaningfully resected by careful microsurgical technique.

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References

  1. Baleriaux DL: Spinal cord tumors. Eur Radiol 9: 1252-1258, 1999

    Google Scholar 

  2. Aubin ML, Jardin C, Bar D, Vignaud J: Computerized tomography in 32 cases of intraspinal tumor. J Neuroradiol 6: 81-92, 1979

    Google Scholar 

  3. Brotchi J, Dewitte O, Levivier M, Balériaux D, Vandesteene A, Raftopoulos C, Flament-Durand J, Noterman J: A survey of 65 tumors within the spinal cord: surgical results and the importance of preoperative magnetic resonance imaging. Neurosurgery 29: 651-657, 1991

    Google Scholar 

  4. Rothwell CI, Jaspan T, Worthington BS, Holland IM: Gadolinium-enhanced magnetic resonance imaging of spinal tumours. Br J Radiol 62: 1067-1074, 1989

    Google Scholar 

  5. Scotti G, Scialfa G, Colombo N, Landoni L: Magnetic resonance diagnosis of intramedullary tumors of the spinal cord. Neuroradiology 29: 130-135, 1987

    Google Scholar 

  6. Goy A, Pinto R, Raghavendra BN, Epstein F, Kricheff I: Intramedullary spinal cord tumors: MR imaging, with emphasis on associated cysts. Radiology 161: 381-386, 1986

    Google Scholar 

  7. Fu Y, Chen ATL, Kay S, Young HF: Is subpendymoma an astrocytoma or ependymoma? A comparative ultrastructural and tissue culture study. Cancer 34: 1992-2008, 1974

    Google Scholar 

  8. Moss TH: Observations on the nature of subependymomas on electron microscopic study. Neuropathol Appl Neurobiol 10: 63-75, 1984

    Google Scholar 

  9. Guha A, Resch L, Tator CH: Subependymoma of the thoracolumbar cord. Case report. J Neurosurg 71: 781-787, 1989

    Google Scholar 

  10. Quinn B: Synaptophysin staining for ganglioglioma. Am J Neuroradiol 20: 526-529, 1999

    Google Scholar 

  11. Thakkar SD, Feigen U, Mautner VF: Spinal tumours in neurofibromatosis type 1: an MRI study of frequency. Neuroradiology 41: 625-629, 1999

    Google Scholar 

  12. Baker KB, Moran CJ, Wippold FJ 2nd, Smirniotopoulos JG, Rodriguez FJ, Meyers SP, Siegal TL: MR imaging of spinal hemangioblastoma. Am J Roentgenol 174: 377-382, 2000

    Google Scholar 

  13. Prayson RA: Clinicopathologic study of 61 patients with ependymoma including MIB-1 immunohistochemistry. Ann Diagn Pathol 3: 11-18, 1999

    Google Scholar 

  14. Brown DF, Gazdar AF, White CL 3rd, Yashima K, Shay JW, Rushing EJ: Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas. J Neuropathol Exp Neurol 56: 1349-1355, 1997

    Google Scholar 

  15. Iwata K, Nakagawa H, Hashizume Y: Significance of MIB-1, PCNA indices, and p53 protein over-expression in intramedullary tumors of the spinal cord. Noshuyo Byori 13: 73-78, 1996

    Google Scholar 

  16. Patel RJ, Appukuttan B, Ott S, Wang X, Stout JT: DNA-based diagnosis of the von Hippel-Lindau syndrome. Am J Ophthalmol 129: 258-260, 2000

    Google Scholar 

  17. Dal Cin P, Van den Berghe H, Buonamici L, Losi L, Roncaroli F, Calbucci F: Cytogenetic investigation in subependymoma. Cancer Genet Cytogenet: 108: 84, 1999

    Google Scholar 

  18. Fuller GN, Goodman JC: Contemporary Neuropathology. Lippincott, Williams & Willins, Philadelphia, 2001 (in press)

    Google Scholar 

  19. Slooff J, Kernohan J, MacCarty C: Primary Intramedullary Tumors of the Spinal Cord and Filum Terminale. W.B. Saunders Company, Philadelphia, 1964

    Google Scholar 

  20. Guidetti B, Mercuri S, Vagnozzi R: Long-term results of the surgical treatment of 129 intramedullary spinal gliomas. J Neurosurg 54: 323-330, 1981

    Google Scholar 

  21. Vinken PJ, Bruyn GW: Handbook of Clinical Neurology, Volumes 19 and 20. Tumors of the Spine and Spinal Cord Part I and II. American Elsevier Publ Co., Inc., New York, 1976

    Google Scholar 

  22. Hirano A: Neuropathology of tumors of the spinal cord: the Montefiore experience. Brain Tumor Pathol 14: 1-4, 1997

    Google Scholar 

  23. Hughes J: Pathology of the Spinal Cord. W.B. Saunders Company, Philadelphia, 1978, pp 218-241

    Google Scholar 

  24. Constantini S, Houten J, Miller DC, Freed D, Ozek MM, Rorke LB, Allen JC, Epstein FJ: Intramedullary spinal cord tumors in children under the age of 3 years. J Neurosurg 85: 1036-1043, 1996

    Google Scholar 

  25. Samii M, Klekamp J: Surgical results of 100 intramedullary tumors in relation to accompanying syringomyelia. Neurosurgery 35: 865-873, 1994

    Google Scholar 

  26. Pullicino P, Kendall B: Computed tomography of "cystic" intramedullary lesions. Neuroradiology 23: 117-121, 1982

    Google Scholar 

  27. Zavala LM, Adler JR, Greene CS, Winston KR: Hydrocephalus and intraspinal tumor. Neurosurgery 22: 751-754, 1988

    Google Scholar 

  28. Mock A, Levi A, Drake JM: Spinal hemangioblastoma, syrinx, and hydrocephalus in a two-year-old child. Neurosurgery 27: 799-802, 1990

    Google Scholar 

  29. Costigan DA, Winkelman MD: Intramedullary spinal cord metastasis. A clinicopathogical study of 13 cases. J Neurosurg 62: 227-233, 1985

    Google Scholar 

  30. Mottl H, Koutecky J: Treatment of spinal cord tumors in children. Med Ped Oncol 29: 293-295, 1997

    Google Scholar 

  31. Epstein F, Ragheb J: Intramedullary tumors of the spinal cord. In: Cheek W, Marlin A, McLone D, Reigel D, Walker M (eds) Pediatric Neurosurgery, 3rd Edition. W.B. Saunders Company, Philadelphia, 1994, pp 446-457

    Google Scholar 

  32. Goh K, Velasquez L, Epstein F: Pediatric intramedullary spinal cord tumors: is surgery alone enough? Pediatr Neurosurg 27: 34-39, 1997

    Google Scholar 

  33. Cooper P: Outcome after operative treatment of intramedullary spinal cord tumors in adults: intermediate and long-term results in 51 patients. Neurosurgery 25: 855-859, 1989

    Google Scholar 

  34. Yasargil MG, Antic J, Laciga R, de Preux J, Fideler RW, Boone SC: The microsurgical removal of intramedullary spinal hemangioblastomas: report of twelve cases and a review of the literature. Surg Neurol 6: 141-148, 1976

    Google Scholar 

  35. Avila N, Shawker T, Choyke P, Oldfield E: Cerebellar and spinal hemangioblastomas: evaluation with intraoperative gray-scale and color doppler flow ultrasound. Radiology 188: 143-147, 1993

    Google Scholar 

  36. Prestor B, Golob P: Intra-operative spinal cord neuromonitoring in patients operated on for intramedullary tumors and syringomyelia. Neurol Res 21: 125-129, 1999

    Google Scholar 

  37. Menezes A, Sonntag V: Principles of Spinal Surgery, Volume 2. McGraw-Hill, New York, 1996

    Google Scholar 

  38. Herrmann HD, Neuss M, Winkler D: Intramedullary spinal cord tumors resected with CO2 laser microsurgical technique: recent experience in fifteen patients. Neurosurgery 22: 518-522, 1988

    Google Scholar 

  39. Salcman M, Mayer R: Intramedullary subependymoma of the cervical spinal cord: case report. Neurosurgery 14: 608-611, 1984

    Google Scholar 

  40. Murota T, Symon L: Surgical management of hemangioblastoma of the spinal cord: a report of 18 cases. Neurosurgery 25: 699-708, 1989

    Google Scholar 

  41. Neumann HPH, Eggert HR, Weigel K, Friedburg H, Wiestler OD, Schollmeyer P: Hemangioblastomas of the central nervous system. A 10-year study with special reference to von Hippel-Lindau syndrome. J Neurosurg 70: 24-30, 1989

    Google Scholar 

  42. Xu Q, Bao W, Mao R, Yang G: Magnetic resonance imaging and microsurgical treatment of intramedullary hemangioblastoma of the spinal cord. Neurosurgery 35: 671-676, 1994

    Google Scholar 

  43. Kane PJ, el-Mahdy W, Singh A, Powell MP, Crockard HA: Spinal intradural tumours: Part II-Intramedullary. Br J Neurosurg 13: 558-563, 1999

    Google Scholar 

  44. Zevgaridis D, Medele RJ, Hamburger C, Steiger HJ, Reulen HJ: Cavernous haemangiomas of the spinal cord. A review of 117 cases. Acta Neurochir 141: 237-245, 1999

    Google Scholar 

  45. Ujiie H, Kubo O, Shimizu T, Kawamura H, Kagawa, Kagawa M: Intramedullary hemangiopericytoma of the spinal cord: case report and review of the literature. No Shinkei Geka 18: 273-277, 1990

    Google Scholar 

  46. Boughey AM, Fletcher NA, Harding AE: Central nervous system hemangioblastoma: a clinical and genetic study of 52 cases. J Neurol Neurosurg Psychiatry 53: 644-648, 1990

    Google Scholar 

  47. Spetzger U, Bertalanffy H, Huffmann B, Mayfrank L, Reul J, Gilsbach JM: Hemangioblastomas of the spinal cord and the brainstem: diagnostic and therapeutic features. Neurosurg Rev 19: 147-151, 1996

    Google Scholar 

  48. Kachhara R, Nair S, Radhakrishnan VV: Sellar-sphenoid sinus hemangioblastoma: case report. Surg Neurol 50: 461-464, 1998

    Google Scholar 

  49. Christante L, Herrmann HD: Surgical management of intramedullary hemangioblastoma of the spinal cord. Acta Neurochir 141: 333-340, 1999

    Google Scholar 

  50. Corr P, Dicker T, Wright M: Exophytic intramedullary hemangioblastoma presenting as an extramedullary mass on myelography. Am J Neuroradiol 16: 883-884, 1995

    Google Scholar 

  51. Minami M, Hanakita J, Suwa H, Suzui H, Fujita K, Nakamura T: Cervical hemangioblastoma with a past history of subarachnoid hemorrhage. Surg Neurol 49: 278-281, 1998

    Google Scholar 

  52. Cerejo A, Vaz R, Feyo PB, Cruz C: Spinal cord hemangioblastoma with subarachnoid hemorrhage. Neurosurgery 27: 991-993, 1990

    Google Scholar 

  53. Kormos RL, Tucker WS, Bilbao JM, Gladstone RM, Bass AG: Subarachnoid hemorrhage due to a spinal cord hemangioblastoma: case report. Neurosurgery 6: 657-660, 1980

    Google Scholar 

  54. Djindjian M, Djindjian R, Houdart R, Hurth M: Subarachnoid hemorrhage due to intraspinal tumors. Surg Neurol 9: 223-229, 1978

    Google Scholar 

  55. Yu JS, Short MP, Schumacher J, Chapman PH, Harsh GR IV: Intramedullary hemorrhage in spinal cord hemangioblastoma. Report of two cases. J Neurosurg 81: 937-940, 1994

    Google Scholar 

  56. Mascalchi M, Padovani R, Taiuti R, Quilici N: Syringomyelia in myotonic dystrophy due to spinal hemangioblastoma. Surg Neurol 50: 446-448, 1998

    Google Scholar 

  57. Wilkins R: A problem of cervical pain. Neurosurgery 36: 158-165, 1995

    Google Scholar 

  58. Solomon R, Stein B: Unusual spinal cord enlargement related to intramedullary hemangioblastoma. J Neurosurg 68: 550-553, 1988

    Google Scholar 

  59. Shi HB, Suh DC, Lee HK, Lim SM, Kim DH, Choi CG, Lee CS, Rhim SC: Preoperative transarterial embolization of spinal tumor: embolization techniques and results. Am J Neuroradiol 20: 2009-2015, 1999

    Google Scholar 

  60. Kaye A, Laws E Jr: Brain Tumors: An Encyclopedic Approach. Churchill Livingstone, New York, 1997

    Google Scholar 

  61. Choi IS, Tantivatana J: Neuroendovascular management of intracranial and spinal tumors. Neurosurg Clin N Am 11: 167-185, 2000

    Google Scholar 

  62. Vazquez-Anon V, Botella C, Beltran A, Solera M, Piquer J: Preoperative embolization of solid cervicomedullary junction hemangioblastomas: report of two cases. Neuroradiology 39: 86-89, 1997

    Google Scholar 

  63. Bergman T, Haines S: Subependymoma of the cervical spinal cord: a case report of long-term survival. Minn Med 74: 21-24, 1991

    Google Scholar 

  64. Lee KS, Angelo JN, McWhorter JM, Davis CH Jr: Symptomatic subependymoma of the cervical spinal cord. Report of two cases. J Neurosurg 67: 128-131, 1987

    Google Scholar 

  65. Casey A, Marsh H, Wilkins P: Subependymoma of the thoracic cord: potential pitfalls in diagnosis. Br J Neurosurg 7: 319-322, 1993

    Google Scholar 

  66. Bret P, Bougeard R, Saint-Pierre G, Guyotat J, Ricci AC, Confavreux, C: Intramedullary subependymoma of the cervical spinal cord. Review of the literature à propos of a case. Neurochirurgie 43: 158-163, 1997

    Google Scholar 

  67. Bardella L, Artico M, Nucci F: Intramedullary subependymoma of the cervical spinal cord. Surg Neurol 29: 326-329, 1988

    Google Scholar 

  68. Jallo GI, Zagzag D, Epstein F: Intramedullary subependymoma of the spinal cord. Neurosurgery 38: 251-257, 1996

    Google Scholar 

  69. Matsumura A, Nose T, Hori A: Intramedullary subependymoma of the spinal cord. Neurosurgery 39: 879, 1996

    Google Scholar 

  70. Pagni CA, Canavero S, Giordana MT, Mascalchi M, Arnetoli G: Spinal intramedullary subependymomas: case report and review of the literature. Neurosurgery 30: 115-117, 1992

    Google Scholar 

  71. Tacconi L, Johnston FG, Thomas D: Subependymoma of the cervical cord: case report. Clin Neurol Neurosurg 98: 24-26, 1996

    Google Scholar 

  72. Vaquero J, Martinez R, Vegazo I, Pontón P: Subependymoma of the cervical spinal cord. Neurosurgery 24: 625-627, 1989

    Google Scholar 

  73. Hoeffel C, Boukobza M, Polivka M, Lot G, Guichard JP, Lafitte F, Reizine D, Merland JJ: MR manifestations of subependymomas. Am J Neuroradiol: 16: 2121-2129, 1995

    Google Scholar 

  74. Prayson RA, Suh JH: Subependymomas: clinicopathologic study of 14 tumors, including comparative MIB-1 immunohistochemical analysis with other ependymal neoplasms. Arch Pathol Lab Med 123: 306-309, 1999

    Google Scholar 

  75. Cervos-Navarro JA, Perez-Cano A: Clinical and immunohistological findings in subependymomas of the spinal cord. Verh Dtsch Ges Pathol 70: 376-379, 1986

    Google Scholar 

  76. Pluchino F, Lodrini S, Lasio G, Allegranza A: Complete removal of holocord subependymoma. Case report. Acta Neurochir 73: 243-250, 1984

    Google Scholar 

  77. Matsumura A, Hori A, Spoerri O: Spinal subependymoma presenting as an extramedullary tumor: case report. Neurosurgery 23: 115-117, 1988

    Google Scholar 

  78. Raina V, Kamble R, Tanwar R, Singh SP, Sharma S: Spinal ganglioneuroblastoma-complete response to chemotherapy alone. Postgrad Med J 69: 746-748, 1993

    Google Scholar 

  79. Ng THK, Fung CF, Goh W, Wong VCN: Ganglioneuroma of the spinal cord. Surg Neurol 35: 147-151, 1991

    Google Scholar 

  80. Furie D, Felsberg G, Tien R, Friedman HS, Fuchs H, McLendon R: MRI of gangliocytoma of cerebellum and spinal cord. Case report. J Comput Assist Tomogr 17: 488-491, 199

    Google Scholar 

  81. Kalyanaraman U, Henderson J: Intramedullary ganglioneuroma of spinal cord: a clinicopathologic study. Human Pathol 13: 952-955, 1982

    Google Scholar 

  82. Cheung YK, Fung CF, Chan FL, Leong L: MRI features of spinal ganglioglioma. Clin Imaging 15: 109-112, 1991

    Google Scholar 

  83. Sawin PD, Theodore N, Rekate HL: Spinal cord ganglioglioma in a child with neurofibromatosis Type 2. Case report & literature review. J Neurosurg: Spine 90: 231-233, 1999

    Google Scholar 

  84. Yamamoto T, Komori T, Shibata N, Toyoda C, Kobayashi M: Multifocal neurocytoma/gangliocytoma with extensive leptomeningeal dissemination in the brain and spinal cord. Am J Surg Pathol 20: 363-370, 1996

    Google Scholar 

  85. Wald U, Levy PJ, Rappaport ZH, Michowitz SD, Schuger L, Shalit MN: Conus ganglioglioma in a 2\(\frac{1}{2}\)-year-old boy. Case report. J Neurosurg 62: 142-144, 1985

    Google Scholar 

  86. Silver JM, Rawlings CE III, Rossitch E Jr, Zeidman SM, Friedman AH: Ganglioglioma: a clinical study with long-term follow-up. Surg Neurol 35: 261-266, 1991

    Google Scholar 

  87. Johannsson JH, Rekate HL, Roessmann U: Gangliogliomas: pathological and clinical correlation. J Neurosurg 54: 58-63, 1981

    Google Scholar 

  88. Mickle JP: Ganglioglioma in children. A review of 32 cases at the University of Florida. Pediatr Neurosurg 18: 310-314, 1992

    Google Scholar 

  89. Kernohan J, Learmonth J, Doyle J: Neuroblastomas and gangliocytomas of the central nervous system. Brain 55: 287-311, 1932

    Google Scholar 

  90. Hamberger C, Büttner A, Weis S: Ganglioglioma of the spinal cord: report of two rare cases and review of the literature. Neurosurgery 41: 1410-1416, 1997

    Google Scholar 

  91. Nakajima M, Kidooka M, Nakasu S: Anaplastic ganglioglioma with dissemination to the spinal cord: a case report. Surg Neurol 49: 445-448, 1998

    Google Scholar 

  92. Albright L, Byrd R: Ganglioglioma of the entire spinal cord. Child's Brain 6: 274-280, 1980

    Google Scholar 

  93. Lang F, Epstein F, Ransohoff J, Allen J, Wisoff J, Abbott IR, Miller D: Central nervous system gangliogliomas. Part 2: clinical outcome. J Neurosurg 79: 867-873, 1993

    Google Scholar 

  94. Constantini S, Miller D: Diagnosis of ganglioglioma. J Neurosurg 88: 935-937, 1998

    Google Scholar 

  95. Miller D, Lang F, Epstein F: Central nervous system gangliogliomas. Part 1: pathology. J Neurosurg 79: 859-866, 1993

    Google Scholar 

  96. Peretti-Viton P, Perez-Castillo AM, Raybaud C, Grisoli F, Bernard F, Poncet M, Salamon G: Magnetic resonance imaging in gangliogliomas and gangliocytomas of the nervous system. J Neuroradiol 18: 189-199, 1991

    Google Scholar 

  97. Castillo M: Gangliogliomas: ubiquitous or not? Am J Neuroradiol 19: 807-809, 1998

    Google Scholar 

  98. Patel U, Pinto R, Miller D, Handler M, Rorke L, Epstein F, Kricheff I: MR of spinal cord ganglioglioma. Am J Neuroradiol 19: 879-887, 1998

    Google Scholar 

  99. Norenberg M: Gangliogliomas: issues of prognosis and treatment. Am J Neuroradiol 19: 810, 1998

    Google Scholar 

  100. Sfakianakis G: Preoperative grading of gangliogliomas using FDG PET and TI-201 SPECT: comments from a nuclear medicine view. Am J Neuroradiol 19: 811, 1998

    Google Scholar 

  101. Schiff D, O'Neill BP: Intramedullary spinal cord metastases: clinical features and treatment outcome. Neurology 47: 906-912, 1996

    Google Scholar 

  102. Kurtz JE, Andres E, Filippi de la Palavesa MM, Deplanque G, Limacher JM, Duclos B, Bergerat JP: L'intérêt de l'IRM dans la détection des métastases intramédullaires: à propos d'une observation. Bull Cancer 81: 808-810, 1994

    Google Scholar 

  103. Jardin F, Stamatoullas A, Fruchart C, D'Anjou J, Clement JF, Tilly H: Intramedullary spinal cord metastasis and leptomeningeal involvement in Hodgkin's disease. Case report and review of the literature. Rev Med Interne 20: 267-271, 1999

    Google Scholar 

  104. Zumpano BJ: Spinal intramedullary metastatic medulloblastoma: case report. J Neurosurg 48: 632-635, 1978

    Google Scholar 

  105. Perkkiö M, Majuri S, Hänninen A, Paljärvi L: A child with esthesioneuroblastoma with metastases to the spinal cord and the bone marrow. Med Ped Oncology 19: 66-69, 1991

    Google Scholar 

  106. Connolly ES Jr, Winfree CJ, McCormick PC, Cruz M, Stein BM: Intramedullary spinal cord metastasis: report of three cases and review of the literature. Surg Neurol 46: 329-338, 1996

    Google Scholar 

  107. Findlay JM, Bernstein M, Vanderlinden RG, Resch L: Microsurgical resection of solitary intramedullary spinal cord metastases. Neurosurgery 21: 911-915, 1987

    Google Scholar 

  108. Markus J: Magnetic resonance imaging of intramedullary spinal cord metastases. Clin Imaging 20: 238-242, 1996

    Google Scholar 

  109. Schwechheimer K, Lemminger JM: Intramedullary metastases: report of 4 cases and review of the literature. Clin Neuropathol 4: 28-37, 1985

    Google Scholar 

  110. Grem JL, Burgess J, Trump DL: Clinical features and natural history of intramedullary spinal cord metastasis. Cancer 56: 2305-2314, 1985

    Google Scholar 

  111. Amin R: Intramedullary spinal metastasis from carcinoma of the cervix. A case report. Br J Radiol 72: 89-91, 1999

    Google Scholar 

  112. Arrotegui JI, Barrios C: Spinal cord and bone metastasizing renal tumor of childhood. Rev Neurol 24: 1231-1232, 1995

    Google Scholar 

  113. Moffie D, Stefanko SZ: Intramedullary metastasis. Clin Neurol Neurosurg 82(3): 199-202, 1980

    Google Scholar 

  114. Ferroir J, Cadranel J, Khalil A, Lebreton C, Contant C, Milleron B: Intramedullary metastases of bronchogenic carcinoma. Two cases. Rev Neurol (Paris) 154: 166-169, 1998

    Google Scholar 

  115. Winkelman MD, Adelstein DJ, Karlins NL: Intramedullary spinal cord metastasis. Diagnostic and therapeutic considerations. Arch Neurol 44: 526-531, 1987

    Google Scholar 

  116. Crasto S, Duca S, Davini O, Rizzi L, Pavanello IG, Avataneo T, Cirillo S, Regge D, Soffietti R: MRI diagnosis of intramedullary metastases from extra-CNS tumors. Eur Radiol 7: 732-736, 1997

    Google Scholar 

  117. Weitzner S: Coexistent intramedullary metastasis and syringomyelia of cervical spinal cord: report of a case. Neurology 19: 674-678, 1969

    Google Scholar 

  118. Keung YK, Cobos E, Whitehead RP, Roberson GH: Secondary syringomyelia due to intramedullary spinal cord metastasis. Case report and review of the literature. Am J Clin Oncol 20: 577-579, 1997

    Google Scholar 

  119. Kepes J, Belton K, Roessmann U, Ketcherside: Primitive neuroectodermal tumors of the cauda equina in adults with no detectable primary intracranial neoplasm-three case studies. Clin Neuropathol 4: 1-11, 1985

    Google Scholar 

  120. Kosnik E, Boesel C, Bay J, Sayers M: Primitive neuroectodermal tumors of the central nervous system in children. J Neurosurg 48: 741-746, 1978

    Google Scholar 

  121. Rodriguez-Ku RJ, Trejo-Castillo W, Rodriguez-Moguel L: Spinal primitive neuroectodermal tumor. Gaceta Medica De Mexico 135: 183-188, 1999

    Google Scholar 

  122. Becker L, Hinton D: Primitive neuroectodermal tumors of the central nervous system. Human Pathol 14: 538-550, 1983

    Google Scholar 

  123. Jaksche H, Wöckel W, Wernert N: Primary spinal medulloblastomas? Neurosurg Rev 11: 259-265, 1988

    Google Scholar 

  124. Sevick RJ, Johns RD, Curry BJ: Primary spinal primitive neuroectodermal tumor with extraneural metastases. Am J Neuroradiol 8: 1151-1152, 1987

    Google Scholar 

  125. Kwon OK, Wang K-C, Kim CJ, Kim IO, Chi J, Cho B-K: Primary intramedullary spinal cord primitive neuroectodermal tumor with intracranial seeding in an infant. Childs Nerv Syst 12: 633-636, 1996

    Google Scholar 

  126. Smith D, Hardman J, Earle K: Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 31: 50-58, 1969

    Google Scholar 

  127. Deme S, Ang L-C, Skaf G, Rowed D: Primary intramedullary primitive neuroectodermal tumor of the spinal cord: case report and review of the literature. Neurosurgery 41: 1417-1420, 1997

    Google Scholar 

  128. Freyer D, Hutchinson R, McKeever P: Primary primitive neuroectodermal tumor of the spinal cord associated with neural tube defect. Pediatr Neurosci 15: 181-187, 1989

    Google Scholar 

  129. Ogasawara H, Kiya K, Kurisu K, Muttaqin Z, Uozumi T, Sugiyama K, Kawamoto Y, Iida K: Intracranial metastasis from a spinal cord primitive neuroectodermal tumor: case report. Surg Neurol 37: 307-312, 1992

    Google Scholar 

  130. Meltzer C, Townsend D, Kottapally S, Jadali F: FDG imaging of spinal cord primitive neuroectodermal tumor. J Nucl Med 39: 1207-1209, 1998

    Google Scholar 

  131. Schochet SS, Violett TW, Nelson J, Pelofsky S, Barnes PA: Polar spongioblastoma of the cervical spinal cord: case report. Clin Neuropathol 3: 225-227, 1984

    Google Scholar 

  132. Herpers MJHM, Freling G, Beuls EAM: Pleomorphic xanthoastrocytoma in the spinal cord: case report. J Neurosurg 80: 564-569, 1994

    Google Scholar 

  133. Alvisi C, Cerisoli M, Giulioni M: Intramedullary spinal gliomas: long-term results of surgical treatments. Acta Neurochir 70: 169-179, 1984

    Google Scholar 

  134. Carstens PHB, Johnson GS, Jelsma L: Spinal gliosarcoma: a light, immunohistochemical and ultrastructural study. Annals Clin Lab Sci 25: 241-246, 1995

    Google Scholar 

  135. Pagni CA, Canavero S, Gaidolfi E: Intramedullary "holocord" oligodendroglioma: case report. Acta Neurochir 113: 96-99, 1991

    Google Scholar 

  136. Gilmer-Hill HS, Ellis WG, Imbesi SG, Boggan JE: Spinal oligodendroglioma with gliomatosis in a child. Case report. J Neurosurg 92: 109-113, 2000

    Google Scholar 

  137. Merchant TE, Nguyen D, Thompson SJ, Reardon DA, Kun LE, Sanford R: High-grade pediatric spinal cord tumors. Pediatr Neurosurg 30: 1-5, 1999

    Google Scholar 

  138. Fortuna A, Celli P, Palma L: Oligodendrogliomas of the spinal cord. Acta Neurochir 52: 305-329, 1980

    Google Scholar 

  139. Ushida T, Sonobe H, Mizobuchi H, Toda M, Tani T, Yamamoto H: Oligodendroglioma of the "widespread" type in the spinal cord. Childs Nerv Syst 14: 751-755, 1998

    Google Scholar 

  140. O'Brien CP, Lehrer HZ, Harkin JC: Extensive oligodendrogliomas of the spinal cord with associated bone changes. Neurology 18: 887-890, 1968

    Google Scholar 

  141. Sharma V, Newton G: Cervical intramedullary neurofibroma. J Korean Med Sci 5:165-167, 1990

    Google Scholar 

  142. Acciarri N, Padovani R, Riccioni L: Intramedullary melanotic schwannoma. Report of a case and review of the literature. Br J Neurosurg 13: 322-325, 1999

    Google Scholar 

  143. Melancia JL, Pimentel JC, Conceição I, Antunes JL: Intramedullary neuroma of the cervical spinal cord: case report. Neurosurgery 39: 594-598, 1996

    Google Scholar 

  144. Innocenzi G, Cervoni L, Caruso R: Intramedullary cervical neurinoma. A case report and review of the literature. Minerva Chirurgica 52: 679-682, 1997

    Google Scholar 

  145. Lee D, Chung C, Kim H: Thoracic intramedullary schwannoma. A case report. J Spinal Disorders 12: 174-176, 1999

    Google Scholar 

  146. Beskonakh E, Cayh S, Turgut M, Bostanci U, Seckin S, Yalcinlar Y: Intraparenchymal schwannomas of the central nervous system: an additional case report and review. Neurosurg Rev 20: 139-144, 1997

    Google Scholar 

  147. Ross DA, Edwards MSB, Wilson CB: Intramedullary neurilemomas of the spinal cord: report of two cases and review of the literature. Neurosurgery 19: 458-464, 1986

    Google Scholar 

  148. Jacquet G, Czorny A, Godard J, Steimle R, Wendling D: Neurinome intramédullaire. À propos d'un cas. Revue de la litteraturé. Neurochirurgie 38: 315-321, 1992

    Google Scholar 

  149. Solomon RA, Handler MS, Sedelli RV, Stein BM: Intramedullary melanotic schwannoma of the cervicomedullary junction. Neurosurgery 20: 36-38, 1987

    Google Scholar 

  150. Marchese MJ, McDonald JV: Intramedullary melanotic schwannoma of the cervical spinal cord: report of a case. Surg Neurol 33: 353-355, 1990

    Google Scholar 

  151. Horowitz MB, Hall WA: Central nervous system germinomas. Arch Neurol 48: 652-657, 1991

    Google Scholar 

  152. Itoh Y, Mineura K, Sasajima H, Kowada M: Intramedullary spinal cord germinoma: case report and review of the literature. Neurosurgery 38: 187-191, 1996

    Google Scholar 

  153. Matsuoka S, Itoh M, Shinonome T, Tanimura A: Intramedullary spinal cord germinoma: case report. Surg Neurol 35: 122-126, 1991

    Google Scholar 

  154. Matsuyama Y, Nagasaka T, Mimatsu K, Inoue K, Mii K, Iwata H: Intramedullary spinal cord germinoma. Spine 20: 2338-2340, 1995

    Google Scholar 

  155. Hisa S, Morinaga S, Kobayashi Y, Ojima M, Chikaoka H, Sasano N: Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy. Cancer 55: 2845-2849, 1985

    Google Scholar 

  156. Slagel D, Goeken J, Platz C, Moore S: Primary germinoma of the spinal cord: a case report with 28-year follow-up and review of the literature. Acta Neuropathol 90: 657-659, 1995

    Google Scholar 

  157. Miyauchi A, Matsumoto K, Kohmura E, Doi T, Hashimoto K, Kawano K: Primary intramedullary spinal cord germinoma. Case report. J Neurosurg 84: 1060-1061, 1996

    Google Scholar 

  158. Shibamoto Y, Asato R, Abe M: Spinal metastasis from occult intracranial germinoma mimicking primary intramedullary tumour. Neuroradiology 36: 137-138, 1994

    Google Scholar 

  159. de Monleon JV, Simonin G, Pincemaille O, Buttin C, Sarles J: Puberte précoce secondaire à un germinome intramédullaire. Arch Pediatr 6: 46-49, 1999

    Google Scholar 

  160. Hamabuchi M, Hasegawa R, Murase T: Teratoma of the spinal cord. A case report with CT scans. J Bone Joint Surg 71B: 390-392, 1989

    Google Scholar 

  161. Al-Sarraj ST, Parmar D, Dean AF, Phookun G, Bridges LR: Clinicopathological study of seven cases of spinal cord teratoma: a possible germ cell origin. Histopathology 32: 51-56, 1998

    Google Scholar 

  162. Poeze M, Herpers MJ, Tjandra B, Freling G, Beuls EA: Intramedullary spinal teratoma presenting with urinary retention: case report and review of the literature. Neurosurgery 45: 379-385, 1999

    Google Scholar 

  163. Hader WJ, Steinbok P, Poskitt K, Hendson G: Intramedullary spinal teratoma and diastematomyelia. Case report and review of the literature. Pediatr Neurosurg 30: 140-145, 1999

    Google Scholar 

  164. Nicoletti GF, Passanisi M, Platania N, Lanzafame S, Albanese V: Intramedullary spinal cystic teratoma of the conus medullaris with caudal exophytic development: case report. Surg Neurol 41: 106-111, 1994

    Google Scholar 

  165. Lunardi P, Missori P, Gagliardi F, Fortuna A: Long-term results of the surgical treatment of spinal dermoid and epidermoid tumors. Neurosurgery 25: 860-864, 1989

    Google Scholar 

  166. Gallina P, Roux FX, Lo Re F, Conti P, Fallet-Bianco C, Conti R, De Luca G: Un cas rare de kyste épidermoïde intramédullaire observe a l'IRM. Neurochirurgie 38: 372-375, 1992

    Google Scholar 

  167. Benzil DL, Epstein MH, Knuckey NW: Intramedullary epidermoid associated with an intramedullary spinal abscess secondary to a dermal sinus. Neurosurgery 30: 118-121, 1992

    Google Scholar 

  168. Roux A, Mercier C, Larbrisseau A, Dube LJ, Dupuis C, Carpio RD: Intramedullary epidermoid cysts of the spinal cord. Case report. J Neurosurg 76: 528-533, 1992

    Google Scholar 

  169. Lee M, Rezai AR, Abbott R, Coelho DH, Epstein FJ: Intramedullary spinal cord lipomas. J Neurosurg 82: 394-400, 1995

    Google Scholar 

  170. Razack N, Jimenez OF, Aldana P, Ragheb J: Intramedullary holocord lipoma in an athlete: case report. Neurosurgery 42: 394-397, 1998

    Google Scholar 

  171. Ehni G, Love J: Intraspinal lipomas. Report of cases: review of the literature and the clinical and pathologic study. Arch Neurol Psychiat 53: 1-28, 1945

    Google Scholar 

  172. Dyck P: Intramedullary lipoma: diagnosis and treatment. Spine 17: 979-981, 1992

    Google Scholar 

  173. Klisch J, Spreer J, Bloss HG, Baborie A, Hubbe U: Radiological and histological findings in spinal intramedullary angiolipoma. Neuroradiology 41: 584-587, 1999

    Google Scholar 

  174. Bluemke D, Wang H: Primary spinal cord lymphoma: MR appearance. Case report. J Comp Assist Tomogr 14: 812-814, 1990

    Google Scholar 

  175. Slowik F, Mayer Á, Áfra D, Deák G, Hável J: Primary spinal intramedullary malignant lymphoma. A case report. Surg Neurol 33: 132-138, 1990

    Google Scholar 

  176. Mitsumoto H, Breuer A, Lederman RJ: Malignant lymphoma of the central nervous system: a case of primary spinal intramedullary involvement. Cancer 46: 1258-1262, 1980

    Google Scholar 

  177. Drouet A, Caminade V, Guilloton L, Brunot J, Crozes P, Ribot C: Primary intramedullary spinal cord lymphoma in HIV patients. MRI aspects. Rev Neurol (Paris) 155: 1074-1078, 1999

    Google Scholar 

  178. Salpietro FM, Alafaci C, Gervasio O, La Rosa G, Baio A, Francolini DC, Batolo D, Tomasello F: Primary cervical melanoma with brain metastases. Case report and review of the literature. J Neurosurg 89: 659-666, 1998

    Google Scholar 

  179. Bergdahl L, Boquist L, Liliequist B, Thulin C-A, Tovi D: Primary malignant melanoma of the central nervous system: a report of 10 cases. Acta Neurochir 26: 139-149, 1972

    Google Scholar 

  180. Larson T, Houser OW, Onofrio B, Piepgras D: Primary spinal melanoma. J Neurosurg 66: 47-49, 1987

    Google Scholar 

  181. Magni C, Yapo P, Mocaer J, Renjard L, Sonier CB, Cottier JP, Jan M, Laffont J: Mélanome intra-médullaire primitif: à propos d'un cas. J Neuroradiol 23: 41-45, 1996

    Google Scholar 

  182. Yamasaki T, Kikuchi H, Yamashita J, Asato R, Fujita M: Primary spinal intramedullary malignant melanoma: case report. Neurosurgery 25: 117-121, 1989

    Google Scholar 

  183. Vaquero J, de Prado F, Pedrosa M: Primary intraparenchymatous spinal cord melanoma. Spinal Cord 36: 363-365, 1998

    Google Scholar 

  184. Glick R, Baker C, Husain S, Hays A, Hibshoosh H: Primary melanocytomas of the spinal cord: a report of seven cases. Clin Neuropathol 16: 127-132, 1997

    Google Scholar 

  185. Salame K, Merimsky O, Yosipov J, Reider-Groswasser I, Chaitchik S, Ouaknine GE: Primary intramedullary spinal melanoma: diagnostic and treatment problems. J Neuro-Oncol 36: 79-83, 1998

    Google Scholar 

  186. Kanahara T, Hirokawa M, Shimizu M, Terayama K, Nakamura E, Hino Y, Mikawa Y, Manabe T: Solitary fibrous tumor of the spinal cord. Report of a case with scrape cytology. Acta Cytol 43: 425-428, 1999

    Google Scholar 

  187. Riley K, Palmer CA, Oser AB, Paramore CG: Spinal cord hamartoma: case report. Neurosurgery 44: 1125-1127, 1999

    Google Scholar 

  188. Mittler MA, Walters BC, Fried AH, Sotomayor EA, Stopa EG: Malignant glial tumor arising from the site of a previous hamartoma/ganglioglioma: coincidence or malignant transformation? Pediatr Neurosurg 30: 132-134, 1999

    Google Scholar 

  189. Jones M, Rueda-Pedraza ME: Extranodal sinus histiocytosis with massive lymphadenopathy presenting as an intramedullary spinal cord tumor: a case report. Am J Hematol 54: 253-257, 1997

    Google Scholar 

  190. Osenbach RK: Isolated extranodal sinus histiocytosis presenting as an intramedullary spinal cord tumor with paraplegia. J Neurosurg 85: 692-696, 1996

    Google Scholar 

  191. Kook H, Hwang T, Kang H, Kim S, Kim J: Spinal intramedullary granulocytic sarcoma: magnetic resonance imaging. Magn Reson Imaging. 11: 135-137, 1993

    Google Scholar 

  192. Levivier M, Brotchi J, Balériaux D, Pirotte B, Flament-Durand J: Sarcoidosis presenting as an isolated intramedullary tumor. Neurosurgery 29: 271-276, 1991

    Google Scholar 

  193. Bernstein M, Berger M (eds): Neuro-oncology: The Essentials. Thieme Medical Publishers, Inc., New York, 2000, pp 445-464

    Google Scholar 

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  1. Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Daniel J. Miller & Ian E. McCutcheon

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Miller, D.J., McCutcheon, I.E. Hemangioblastomas and Other Uncommon Intramedullary Tumors. J Neurooncol 47, 253–270 (2000). https://doi.org/10.1023/A:1006403500801

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