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A mathematical model for elongation of a peptide chain

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Abstract

A mathematical model is presented for the steps in the elongation process, and the steady-state elongation rate as a function of the amino acid concentrations is found. In addition, the reset sub-process of the elongation process is modeled. The rate of elongation of peptide chains is found to be a function of the concentration of the amino acid to be bound and the concentration of all other amino acids. In addition, the overall elongation rate depends on the concentrations of elongation factors.

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Authors and Affiliations

  1. Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY, 12180-3590, USA

    Andrew Heyd & Donald A. Drew

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  1. Andrew Heyd
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  2. Donald A. Drew
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Correspondence to Donald A. Drew.

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Heyd, A., Drew, D.A. A mathematical model for elongation of a peptide chain. Bull. Math. Biol. 65, 1095–1109 (2003). https://doi.org/10.1016/S0092-8240(03)00076-4

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  • DOI: https://doi.org/10.1016/S0092-8240(03)00076-4

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