Abstract
We present the case of an 83-year-old female patient diagnosed with osteoclastic variant of anaplastic thyroid carcinoma (OVATC), describing clinical presentation, radiological appearance, histopathological and molecular features, local/regional treatment, airway management, and ethical aspects guiding palliative care after curative options were no longer possible. OVATC is a rare tumor with only a few cases reported in the literature; as far as the authors know, this is the first case of OVATC reported with full documentation of clinical and surgical aspects, imaging studies, genetic studies, and cytological and histopathological images.
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Huang N, Shi X, Lei B, Wei W, Lu Z, Yu P, et al. An update of the appropriate treatment strategies in anaplastic thyroid cancer: a population-based study of 735 patients. Int J Endocrinol. 2019;2019:1–7.
Shelly D, Gupta D, Mishra S, Bharadwaj R. Osteoclastic variant of anaplastic thyroid carcinoma: a case report of rare entity. J Cancer Res Ther. 2019;15(3):704–07
Ragazzi M, Ciarrochi A, Sancisi V, Gandolfi G, Bisagni A, Piana S. Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer. Int J Endocrinol. 2014;2014:1–13.
Gaumann A, Hansen T, Kohler H, Kommoss F, Mann W, Maurer J, et al. The expression of cathepsins in osteoclast-like giant cells of an anaplastic thyroid carcinoma with tracheal perforation. Pathol Res Pract. 2001;197:257–62.
Deeken-Draisey A, Yang GY, Gao J, Alexiev BA. Anaplastic thyroid carcinoma: an epidemiologic, histologic, immunohistochemical, and molecular single – institution study. Hum Pathol. 2018;82:140–8.
Kumar PV, Torabinejad S, Omrani GH. Osteoclastoma like anaplastic carcinoma of the thyroid gland diagnosed by fine needle aspiration cytology. Report of two cases. Acta Cytol. 1990;34(2):248–50.
Mehdi G, Ansari HA, Siddiqui SA. Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast – like giant cells – a case report. Diagn Cytopathol. 2007;35:111–2.
Berry B, MacFarlene J, Chan N. Osteoclastoma like anaplastic carcinoma of the thyroid. Diagnosis by fine needle aspiration cytology. Acta Cytol. 1990;34(2):248–50.
Guarda LA, Peterson CE, Hall W, Baskin HJ. Anaplastic thyroid carcinoma: cytomorphology and clinical implications of fine – needle aspiration. Diagn Cytopathol. 1991;7(1):63–7.
Lee JS, Lee MC, Park CS, Juhng SW. Fine needle aspiration cytology of anaplastic carcinoma with osteoclast like giant cells of the thyroid. A case report. Acta Cytol. 1996;40(6):1309–12.
Anaplastic carcinoma of the thyroid with osteoclast – like giant cells. Cancer. 1983;52(11):2122–8.
Valand AG, Ramraje SN, Shedger R, Aware S. Anaplastic thyroid carcinoma with osteoclast – like giant cells. J Assoc Physicians India. 2004;52:585–6.
Gaffey MJ, Lack EE, Christ ML, Weiss LM. Anaplastic thyroid carcinoma with osteoclast – like giant cells. A clinicopathologic, immunohistochemical, and ultrastructural study. Am J Surg Pathol. 1991;15(2):160–8.
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Mario Canales-Medina: conception, design, analysis, drafting, and reviewing of the manuscript.
Luis Alfonso Rodríguez-Palomares: selection of the pictures imaging studies, review, comment and analysis on the imaging studies.
Luisa Fernanda Medina-Rodríguez: compilation, summary and comments on the clinical fine
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No identifiable personal data are mentioned in this report. The patient before passing away, and in turn the family also, gave their explicit consent for the report of the case. This paper was approved for publication by the hospital’s Ethics Committee.
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Canales-Medina, M., Rodríguez-Palomares, L.A. & Medina-Rodríguez, L.F. Osteoclastic Variant of Anaplastic Thyroid Carcinoma—Case Report of a Very Rare Entity. SN Compr. Clin. Med. 3, 370–374 (2021). https://doi.org/10.1007/s42399-020-00708-z
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DOI: https://doi.org/10.1007/s42399-020-00708-z