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Development and characterization of porous bioceramic tablets based on bone powder for medical applications

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Abstract

Multifunctional porous biological hydroxyapatite (b-Hap) tablets prepared from fine bone powder (FBP) are predicted to be useful as a calcium supplement and at the same time as low-dose drug carriers. FBP was hydrothermally extracted, then mechanically compressed and sintered without using chemical additives to prepare the porous b-Hap tablets. The properties of FBP and b-Hap tablets were characterized by XRD, FTIR, SEM, mechanical, and porosity tests. Moreover, an aqueous drug solution of atenolol was used to evaluate release behavior from porous b-Hap tablets. The prepared FBP exhibited microstructures with grain sizes of about 50 to 100 μm while b-Hap tablets sintered at 800 °C exhibited high porosity (55%) and compression strength of 8.5 MPa. When the atenolol-loaded b-Hap tablets were immersed in the acidic medium, the release of atenolol from the tablets continued for 120 min with complete dissolution of the b-Hap tablets. These results indicate that the porous b-Hap tablets are promised as an economic calcium supplement and as low-dose drug carriers.

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References

  1. Xie, L., Yu, H., Deng, Y., Yang, W., Liao, L., Long, Q.: Preparation, characterization and in vitro dissolution behavior of porous biphasic α/β-tricalcium phosphatebioceramics. Mater. Sci. Eng. C. 59, 1007–1015 (2016)

    Article  Google Scholar 

  2. Tao, Z.-S., Zhou, W.-S., Tu, K., Huang, Z.-L., Zhou, Q., Sun, T., Lv, Y.-X., Cui, W., Yang, L.: Effect exerted by teriparatide upon repair function of β-tricalcium phosphate to ovariectomised rat's femoral metaphysis defect caused by osteoporosis. Injury. 46, 2134–2141 (2015)

    Article  Google Scholar 

  3. Morsy, R.: Development and evaluation of degradable hydroxyapatite/sodium silicate composite for low-dose drug delivery systems. Bull. Mater. Sci. 39, 1273–1278 (2016)

    Article  Google Scholar 

  4. Laffargue, P., Fialdes, P., Frayssinet, P., Rtaimate, M., Hildebrand, H.F., Marchandise, X.: Adsorption and release of insulin-like growth factor-I on porous tricalcium phosphate implant. J. Biomed. Mater. Res. 49, 415–421 (2000)

    Article  Google Scholar 

  5. Paul, W., Sharma, C.P.: Tricalcium phosphate delayed release formulation for oral delivery of insulin: a proof-of-concept study. J. Pharm. Sci. 97, 875–882 (2008)

    Article  Google Scholar 

  6. Baradari, H., Damia, C., Dutreih-Colas, M., Laborde, E., Pécout, N., Champion, E., Chulia, D., Viana, M.: Calcium phosphate porous pellets as drug delivery systems: effect of drug carrier composition on drug loading and in vitro release. J. Eur. Ceram. Soc. 32, 2679–2690 (2012)

    Article  Google Scholar 

  7. Gervaso, F., Padmanabhan, S.K., Scalera, F., Sannino, A., Licciulli, A.: Mechanical stability of highly porous hydroxyapatite scaffolds during different stages of in vitro studies. Mater. Lett. 185, 239–242 (2016)

    Article  Google Scholar 

  8. Morsy, R.: Multifunctional antibacterial biocomposite rich of trace elements based on biological hydroxyapatite and ZnO nanoparticles. Rom. J. Biophys. 25, 291–300 (2015)

    Google Scholar 

  9. Miyasaka, R., Kikukawa, K., Sakuma, S.: Enhanced solubility and intestinal absorption of cisplatin by coating with nano-hydroxyapatite. J. Drug Deliv. Sci. Technol. 35, 294–302 (2016)

    Article  Google Scholar 

  10. Roy, A., Jhunjhunwala, S., Bayer, E., Fedorchak, M., Little, S.R., Kumta, P.N.: Porous calcium phosphate-poly (lactic-co-glycolic) acid composite bone cement: a viable tunable drug delivery system. Mater. Sci. Eng. C. 59, 92–101 (2016)

    Article  Google Scholar 

  11. Fereshteh, Z., Fathi, M., Bagri, A., Boccaccini, A.R.: Preparation and characterization of aligned porous PCL/zein scaffolds as drug delivery systems via improved unidirectional freeze-drying method. Mater. Sci. Eng. C. 68, 613–622 (2016)

    Article  Google Scholar 

  12. Ahnfelt, E., Sjögren, E., Hansson, P., Lennernäs, H.: In vitro release mechanisms of doxorubicin from a clinical bead drug-delivery system. J. Pharm. Sci. 105, 3387–3398 (2016)

    Article  Google Scholar 

  13. Terukina, T., Saito, H., Tomita, Y., Hattori, Y., Otsuka, M.: Development and effect of a sustainable and controllable simvastatin-releasing device based on PLGA microspheres/carbonate apatite cement composite: in vitro evaluation for use as a drug delivery system from bone-like biomaterial. J. Drug Deliv. Sci. Technol. 37, 74–80 (2017)

    Article  Google Scholar 

  14. Ma, Y., Ge, Y., Li, L.: Advancement of multifunctional hybrid nanogel systems: construction and application in drug co-delivery and imaging technique. Mater. Sci. Eng. C. 71, 1281–1292 (2017)

    Article  Google Scholar 

  15. Taratula, O., Kuzmov, A., Shah, M., Garbuzenko, O.B., Minko, T.: Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancerdrugs and siRNA. J. Control. Release. 171, 349–357 (2013)

    Article  Google Scholar 

  16. Waheed, S., Rahman, S., Siddique, N.: Calcium supplements as source of trace elements: adequacy and safety of supplements with vitamin C, vitamin D and phosphate formulations. Appl. Radiat. Isot. 89, 134–140 (2014)

    Article  Google Scholar 

  17. Li, M., Zhang, T., Yang, H., Zhao, G., Xu, C.: A novel calcium supplement prepared by phytoferritin nanocages protects against absorption inhibitors through a unique pathway. Bone. 64, 115–123 (2014)

    Article  Google Scholar 

  18. Cosijns, A., Vervaet, C., Luyten, J., Mullens, S., Siepmann, F., Van Hoorebeke, L., Masschaele, B., Cnudde, V., Remon, J.P.: Porous hydroxyapatite tablets as carriers for low-dosed drugs. Eur. J. Pharm. Biopharm. 67, 498–506 (2007)

    Article  Google Scholar 

  19. Morsy, R.: Developing a multifunctional bio-ceramics composite based on b-tricalcium phosphate working as a single carrier for calcium supplement and low-dose drugs. Int. J. Mater. Res. 107, 1062–1064 (2016)

    Article  Google Scholar 

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Authors and Affiliations

  1. Biophysics Laboratory, Physics Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt

    Reda Morsy & Tarek Elnimr

  2. Faculty of Medicine, Radiology Department, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia

    Reda Morsy & Fahd Nasser Al Qahtani

  3. Faculty of Dentistry, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia

    Fahd Nasser Al Qahtani

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  1. Reda Morsy
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  2. Fahd Nasser Al Qahtani
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Correspondence to Reda Morsy.

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Morsy, R., Al Qahtani, F.N. & Elnimr, T. Development and characterization of porous bioceramic tablets based on bone powder for medical applications. J Aust Ceram Soc 54, 331–335 (2018). https://doi.org/10.1007/s41779-017-0157-0

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  • DOI: https://doi.org/10.1007/s41779-017-0157-0

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