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Comparison of Conventional Pap Smear, Colposcopy, and HPV Testing in Diagnosis of CIN

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Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Aim

To access prevalence of repeated smears in routine health screening and comparison of its outcome with colposcopy, and HPV testing in early diagnosis of cervical neoplasia.

Methods

Cross-sectional study. Cervical screening of 1200 healthy patients 21 years and above was carried out at health camp. Conventional Pap staining was done in all cases. Abnormal cases were subjected to further testing. The result of conventional Pap smear, repeat Pap smear, HPV test, and colposcopy was compared in repeated smears.

Statistical Analysis Used

Sensitivity specificity and area under curve (AUC) were calculated with 95% CI with standard histopathology.

Results

31.08% (N = 373) cases were followed by a repeat Pap smear. Sensitivity for conventional Pap smear in detecting CIN was found to be 82.93% and specificity was 84.76%,while sensitivity and specificity for colposcopy were 99.8% and 96.19%, respectively. Sensitivity for HPV in detecting CIN was 48.94%. AUC for Pap was 0.851, 95% CI (0.783–0.905). AUC for colposcopy was 0.981, 95% CI (0.943–0.996).

Conclusion

In a routine health camp, as many as 31.08% of cases were repeated. 12.4% of patient’s Pap was repeatedly abnormal which shows a high prevalence of undetected cervical pathology in population. Our study also shows colposcopy has more sensitivity and specificity in detecting CIN as compared to repeat Pap smear in cases of inflammatory reactive and ASCUS cases. HPV, however, has low sensitivity in comparison with both methods.

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Authors and Affiliations

  1. INHS Asvini, Mumbai, Maharashtra, India

    Ritu Mehta, Rashmi Yadav & C. P. Singh

Authors
  1. Ritu Mehta
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  2. Rashmi Yadav
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  3. C. P. Singh
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Contributions

RM, RY, and CPS involved in concepts and design; RM, RY, and CPS involved in definition of intellectual content, clinical studies, and data acquisition; RM and RY involved in the literature search, data analysis, statistical analysis, manuscript preparation, manuscript editing, and manuscript review; RY involved in guarantor. All authors have read and approved the manuscript.

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Correspondence to Rashmi Yadav.

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Mehta, R., Yadav, R. & Singh, C.P. Comparison of Conventional Pap Smear, Colposcopy, and HPV Testing in Diagnosis of CIN. Indian J Gynecol Oncolog 19, 33 (2021). https://doi.org/10.1007/s40944-021-00512-0

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  • DOI: https://doi.org/10.1007/s40944-021-00512-0

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