Abstract
Background
Preterm birth (PTB) is a major adverse pregnancy outcome and largely contributes to increasing neonatal and maternal mortality. Genetic and environmental factors may play an important role in the development of PTB. Numerous studies have shown that immune genes related to the immune system, such as IL-6, IL-10, and TNFα, are associated with the occurrence of PTB.
Objective
We examined genetic associations between IL-6 rs1800796, IL-10 rs1800872, and TNFα rs1800630 polymorphisms and PTB in Korean women.
Methods
In this study, 115 PTB patients and 147 controls were analyzed. The genotyping of three SNPs was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results
Our result showed that the rs1800872 polymorphism was significantly associated with the development of PTB in genotype frequency (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.01–2.90, p = 0.046). We also found a significant association in an analysis of combined genotypes (rs1800796 CC, rs1800872 CA, and rs1800630 CA) (OR 7.43, 95% CI 2.06–26.84, p = 0.001). In a correlation analysis, rs1800630 A allele was significantly related with the increased birth weight (g) within PTB patients (p = 0.005).
Conclusion
Our results imply possible relationships between the rs1800796, rs1800872, and rs1800630 polymorphisms and the development of PTB.
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We are grateful to all volunteers for providing DNA samples.
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Seung Hun Han, Noo Ri Lee, Hyung Jun Kim, Yun Dan Kang, Jong Soo Kim, Jin Wan Park, Han Jun Jin declare that they have no conflict of interest.
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The study was approved by the Ethics Committee of the Dankook University. Informed consent was obtained from all individual participants included in the study.
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Han, S.H., Lee, N.R., Kim, H.J. et al. Association between the IL-6, IL-10, and TNFα gene polymorphisms and preterm-birth in Korean women. Genes Genom 42, 743–750 (2020). https://doi.org/10.1007/s13258-020-00946-4
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DOI: https://doi.org/10.1007/s13258-020-00946-4