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Development of GLP-1 secretagogue using microarray in enteroendocrine L cells

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Abstract

Glucagon-like peptide-1 (GLP-1) plays glucose homeostasis and delays gastric empty. Because GLP-1 activates GLP-1 receptor and this activation recruits insulin secretion in pancreatic β-cells. This biological action applied therapeutic treatment for type 2 diabetes mellitus using GLP-1 analogues, exendin-4 and lilaglutide. Although therapeutic approaches of GLP-1 analogues are very effective as a hypoglycemic agents, its side effects are occurred in clinical study such as pancreatitis, autoimmune hepatitis and acute kidney injury. To solve critical side effects in therapeutic treatment, alternative ways are still developed. In this review, we introduce the character of taste receptors and taste receptor signaling. Because taste receptors and taste receptor signaling are able to induce GLP-1 release from exogenous molecules in enteroendocrine L cells. And how we find and develop that safe exogenous molecules to induce GLP-1 are in natural resources against side effects. We suggest that mRNA variants of taste receptors and taste receptor signaling molecules are briefly screening to find GLP-1 secret-agogue in natural components including herbal medicines using biochip in enteroendocrine L cells.

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Authors and Affiliations

  1. Department of Biochemistry, Graduate School, Kyung Hee University, Heogi-dong, Dongdaemun-gu, Seoul, 02447, Republic of Korea

    Kang-Hoon Kim & Hyeung-Jin Jang

  2. Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Heogi-dong, Dongdaemun-gu, Seoul, 02447, Republic of Korea

    Kang-Hoon Kim & Hyeung-Jin Jang

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  1. Kang-Hoon Kim
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  2. Hyeung-Jin Jang
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Correspondence to Hyeung-Jin Jang.

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Kim, KH., Jang, HJ. Development of GLP-1 secretagogue using microarray in enteroendocrine L cells. BioChip J 10, 272–276 (2016). https://doi.org/10.1007/s13206-016-0403-5

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