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The Influence of Neoadjuvant Chemotherapy on Breast Conserving Therapy and Post-Mastectomy Radiation Therapy

  • Translational Research (Vered Stearns, Section Editor)
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Abstract

Neoadjuvant chemotherapy (NACT) has revolutionized the management of women with locally advanced breast cancer. Although this change in treatment paradigm has facilitated surgery and helped to predict outcomes in certain subsets of patients, it has also caused some confusion with respect to the role of adjuvant radiation therapy. This review discusses the benefits of NACT, the questions that arose as a result of this change in sequence, and, using the current literature, the possible answers to these questions. The reader should leave this review with a basic understanding of the issues faced by the radiation oncologist when consulting patients who have been treated with NACT.

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Papers of particular interest, published recently, have been highlighted as: •Of importance ••Of major importance

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  1. Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, 401 N. Broadway/Ste 1440, Baltimore, MD, 21231, USA

    Richard C. Zellars

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  1. Richard C. Zellars
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Correspondence to Richard C. Zellars.

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Zellars, R.C. The Influence of Neoadjuvant Chemotherapy on Breast Conserving Therapy and Post-Mastectomy Radiation Therapy. Curr Breast Cancer Rep 3, 220–224 (2011). https://doi.org/10.1007/s12609-011-0058-0

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  • DOI: https://doi.org/10.1007/s12609-011-0058-0

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