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Vitamin K status is not associated with cognitive decline in middle aged adults

  • Published:
The journal of nutrition, health & aging

Abstract

Objectives

The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D.

Design

Longitudinal study with six years follow-up.

Setting

Community based.

Participants

599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years).

Measurements

Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning.

Results

Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p<0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (>406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP.

Conclusion

In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands

    E. G. H. M. van den Heuvel, N. M. van Schoor & M. den Heijer

  2. FrieslandCampina, Amersfoort, The Netherlands

    E. G. H. M. van den Heuvel & R. M. L. Zwijsen

  3. Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands

    M. den Heijer

  4. BioPartner Center, VitaK BV, Maastricht University, Maastricht, The Netherlands

    C. Vermeer

  5. GGZ in Geest/ Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, A.J. Ernststraat 1187, 1081 HL, Amsterdam, The Netherlands

    H. C. Comijs

Authors
  1. E. G. H. M. van den Heuvel
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  2. N. M. van Schoor
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  3. C. Vermeer
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  4. R. M. L. Zwijsen
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  5. M. den Heijer
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  6. H. C. Comijs
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Corresponding author

Correspondence to H. C. Comijs.

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van den Heuvel, E.G.H.M., van Schoor, N.M., Vermeer, C. et al. Vitamin K status is not associated with cognitive decline in middle aged adults. J Nutr Health Aging 19, 908–912 (2015). https://doi.org/10.1007/s12603-015-0579-8

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  • DOI: https://doi.org/10.1007/s12603-015-0579-8

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