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Associations between left ventricular diastolic function and right ventricular function in patients with and without preserved left ventricular ejection fraction

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Abstract

Background

The purpose of this study was to investigate associations between right ventricular (RV) function and left ventricular (LV) diastolic function in patients with reduced LV ejection fraction (LVEF) and preserved LVEF.

Methods

A total of 139 patients who had undergone echocardiography were recruited. LV diastolic function was determined as the ratio of mitral inflow E to mitral e′ lateral annular velocities (E/e′). RV function was determined as the RV index of myocardial performance (RIMP). Patients were divided into two groups: the preserved LVEF group (n = 100, LVEF ≥ 50%) and the reduced LVEF group (n = 39, LVEF <  50%).

Results

Associations between RV function and LV diastolic function in patients with reduced LVEF and preserved LVEF differed significantly. RIMP correlated significantly with E/e′ in patients with reduced LVEF (r = 0.47, p = 0.003), but not in those with preserved LVEF (r = 0.04, p = 0.68). An important finding of the multivariate regression analysis showed that RIMP was the only independent determinant of E/e′ in patients with reduced LVEF, whereas age and gender (not RIMP) was the independent determinant of E/e′ in patients with preserved LVEF.

Conclusions

Associations between RV function and LV diastolic function in patients with reduced LVEF and preserved LVEF differed significantly, and RV function showed a close correlation with LV diastolic function in patients with reduced LVEF, but not in those with preserved LVEF. Thus, these findings may well have clinical implications for better management of patients with reduced LVEF.

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Authors and Affiliations

  1. Division of Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

    Tsumugi Oki, Jun Saegusa, Seiji Kawano & Yoshihiro Nishimura

  2. Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Hidekazu Tanaka & Ken-ichi Hirata

  3. Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan

    Tsumugi Oki, Takamitsu Imanishi, Yuji Nakamachi & Jun Saegusa

Authors
  1. Tsumugi Oki
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  2. Hidekazu Tanaka
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  3. Takamitsu Imanishi
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  4. Yuji Nakamachi
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  5. Jun Saegusa
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  6. Seiji Kawano
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  7. Ken-ichi Hirata
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  8. Yoshihiro Nishimura
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Correspondence to Hidekazu Tanaka.

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Conflict of interest

Tsumugi Oki, Hidekazu Tanaka, Takamitsu Imanishi, Yuji Nakamachi, Jun Saegusa, Seiji Kawano, Ken-ichi Hirata, and Yoshihiro Nishimura declare that they have no conflict of interest.

Funding

Tsumugi Oki, Hidekazu Tanaka, Takamitsu Imanishi, Yuji Nakamachi, Jun Saegusa, Seiji Kawano, Ken-ichi Hirata, and Yoshihiro Nishimura declare that they receive no fundings.

Human rights statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later revisions.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Oki, T., Tanaka, H., Imanishi, T. et al. Associations between left ventricular diastolic function and right ventricular function in patients with and without preserved left ventricular ejection fraction. J Echocardiogr 16, 81–86 (2018). https://doi.org/10.1007/s12574-017-0363-3

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  • DOI: https://doi.org/10.1007/s12574-017-0363-3

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