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Incidence of congenital heart diseases in Chinese children with non-syndromic congenital blepharoptosis: a prospective observational study of 1053 patients

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Abstract

Background

Congenital blepharoptosis (CBP) may be part of a large spectrum of birth defects presenting with other ocular or systemic conditions. Therefore, the aim of the study was to investigate the incidence of congenital heart diseases (CHD) in CBP children not associated with specific syndromes.

Methods

A total of 1053 Chinese children diagnosed with non-syndromic CBP were consecutively enrolled and their cardiac structure was evaluated by echocardiography.

Results

Forty children were identified with CHD. Twenty-four children had one type of structural malformation (simple CHD). Sixteen children had two or more types of structural malformation (complex CHD). CHD and complex CHD were more prevalent in patients with severe or bilateral ptosis. Multivariate analysis revealed that presence of severe ptosis and bilateral ptosis was independently associated with CHD occurrence.

Conclusions

We found an increased frequency of CHD in CBP children, suggesting a clinical need for routine echocardiography evaluation in CBP, especially in children with severe or bilateral ptosis.

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Funding

This work was supported by the National Natural Science Foundation of China grant (Grant no. 81570037) and the MDT Program of Shanghai Ninth People’s Hospital (Grant no. 2017-1-015).

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Authors and Affiliations

  1. Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China

    Le-Feng Zeng, Zheng-De Tang, Jun Gu, Chang-Qian Wang & Hui-Li Zhang

Authors
  1. Le-Feng Zeng
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  2. Zheng-De Tang
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  3. Jun Gu
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  4. Chang-Qian Wang
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  5. Hui-Li Zhang
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Contributions

LFZ and ZDT did echocardiographic examination. LFZ and JG analyzed the data. CQW and HLZ designed the study. HLZ wrote the manuscript. All the authors approved the final version of the manuscript.

Corresponding author

Correspondence to Hui-Li Zhang.

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Ethical approval

The study was approved by the hospital ethnics review board. Individual permission was obtained from all the participants using standard informed consent procedure.

Conflict of interest

No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

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Zeng, LF., Tang, ZD., Gu, J. et al. Incidence of congenital heart diseases in Chinese children with non-syndromic congenital blepharoptosis: a prospective observational study of 1053 patients. World J Pediatr 16, 411–415 (2020). https://doi.org/10.1007/s12519-019-00282-y

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  • DOI: https://doi.org/10.1007/s12519-019-00282-y

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