Skip to main content

Advertisement

SpringerLink
Log in

Ultrasonographic findings of invasive micropapillary carcinoma of the breast: correlation between internal echogenicity and histological findings

  • Original Article
  • Published:
Breast Cancer Aims and scope Submit manuscript

Abstract

Background

Invasive micropapillary carcinoma of the breast (IMPC) has been considered to have no specific image finding. The purpose of this study was to correlate the ultrasonographic findings of IMPC, especially internal echogenicity, with histological findings and to discuss the histological factor that influenced the internal echogenicity.

Methods

Six patients who had undergone surgery at our institute between October 2005 and February 2010 and had been subsequently diagnosed with IMPC were enrolled in this study. Internal echogenicities were correlated with the presence or absence of the central lumens within tumor cell clusters, and with the size of the spaces around these tumor cells.

Results

The internal echogenicities of three IMPCs were isoechoic compared with subcutaneous fat tissue, and those of the other three IMPCs were hypoechoic. All three isoechoic IMPCs had central lumens, while no central lumen was seen in the three hypoechoic IMPCs. There was no relation between the size of spaces around the tumor cells and internal echogenicity. All tumors showed either posterior enhancement or no posterior acoustic feature.

Conclusions

Half of the IMPCs in our study showed isoechogenicity on ultrasonography. The existence of a central lumen in the tumor cell clusters might have contributed to relatively high internal echogenicity of these IMPCs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Gunhan-Blgen I, Zekioglu O, Ustun EE, Memis A, Erhan Y. Invasive micropapillary carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR Am J Roentgenol. 2002;179:927–31.

    Google Scholar 

  2. Adrada B, Arribas E, Gilcease M, Yang WT. Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and MRI features. AJR Am J Roentgenol. 2009;193:W58–63.

    Article  PubMed  Google Scholar 

  3. Siriaunkgul S, Tavassoli FA. Invasive micropapillary carcinoma of the breast. Mod Pathol. 1993;6:660–2.

    PubMed  CAS  Google Scholar 

  4. Ellis IO, Cornelisse CJ, Schnitt SJ, Sasco AJ, Sastre-Garau X, Kaaks R, et al. Tumours of the breast. In: Tavassoli FA, Devilee P, editors. World Health Organization classification of tumours, pathology and genetics of tumours of the breast and female genital organs. Lyon: IARC Press; 2003. p. 9–112.

    Google Scholar 

  5. Rosen PP. Invasive micropapillary carcinoma. In: Rosen PP, editor. Rosen’s breast pathology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 561–4.

    Google Scholar 

  6. Kuroda H, Sakamoto G, Ohnisi K, Itoyama S. Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 2004;11:169–74.

    Article  PubMed  Google Scholar 

  7. Akiyama F, Sakamoto G, Inai K, Kurosumi M, Tsuchiya S, Tsuda H. Histologic classification. In: The Japanese Breast Cancer Society, editor. General Rules for Clinical and Pathological Recording of Breast Cancer. 16th ed. Tokyo: Kanehara & Co., Ltd.; 2008. p. 18–59. (in Japanese).

    Google Scholar 

  8. Lam WW, Chu WC, Tse GM, Ma TK. Sonographic appearance of mucinous carcinoma of the breast. AJR Am J Roentgenol. 2004;182:1069–74.

    PubMed  CAS  Google Scholar 

  9. Memis A, Ozdemir N, Parildar M, Ustun EE, Erhan Y. Mucinous (colloid) breast carcinoma: mammographic and US features with histologic correlation. Eur J Radiol. 2000;35:39–43.

    Article  PubMed  CAS  Google Scholar 

  10. Chopra S, Evans AJ, Pinder SE, Yeoman LJ, Ellis IO, Elston CW, et al. Pure mucinous breast cancer-mammographic and ultrasound findings. Clin Radiol. 1996;51:421–4.

    Article  PubMed  CAS  Google Scholar 

  11. Sakuma H. Genkyoku-gata Shuryu. In: Sakuma H, Obane N, editors. Nyubo Chouonpa Jissen manual. Tokyo: Ishiyaku Publishers, Inc.; 2005. p. 62–9. (in Japanese).

    Google Scholar 

  12. Kamitani K, Ono M, Toyoshima S, Mitsuyama S, Anan K, Ikeda Y. Isoechoic axillary lymph node metastases of mucinous carcinoma of the breast: a case report. Breast Cancer. 2006;13:382–5.

    Article  PubMed  Google Scholar 

  13. Acs G, Paragh G, Chuang ST, Laronga C, Zhang PJ. The presence of micropapillary features and retraction artifact in core needle biopsy material predicts lymph node metastasis in breast carcinoma. Am J Surg Pathol. 2009;33:202–10.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Laboratory, Kitakyushu Municipal Medical Center, 2-1-1, Bashaku, Kokura-kita, Kitakyushu, Fukuoka, 802-0077, Japan

    Kumiko Kamitani

  2. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Takeshi Kamitani

  3. Department of Radiology, Kitakyushu Municipal Medical Center, Kitakyushu, Japan

    Minoru Ono

  4. Department of Pathology, Kitakyushu Municipal Medical Center, Kitakyushu, Japan

    Satoshi Toyoshima

  5. Department of Surgery, Kitakyushu Municipal Medical Center, Kitakyushu, Japan

    Shoshu Mitsuyama

Authors
  1. Kumiko Kamitani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takeshi Kamitani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Minoru Ono
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Satoshi Toyoshima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shoshu Mitsuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kumiko Kamitani.

About this article

Cite this article

Kamitani, K., Kamitani, T., Ono, M. et al. Ultrasonographic findings of invasive micropapillary carcinoma of the breast: correlation between internal echogenicity and histological findings. Breast Cancer 19, 349–352 (2012). https://doi.org/10.1007/s12282-011-0293-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12282-011-0293-2

Keywords

Search

Navigation