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Inhibition of matrix metalloproteinase-1 and type-I procollagen expression by phenolic compounds isolated from the leaves of Quercus mongolica in ultraviolet-irradiated human fibroblast cells

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Abstract

The aim of this study was to investigate the effect of Quercus mongolica (QM) which induce anti-photoaging process of skin in vitro. Bioassay-guided isolation of 80 % Me2CO extract of the leaves of QM led to the isolation and identification of six known phenolic compounds: pedunculagin (1), (−)-epigallocatechin (2), (+)-catechin (3), quercetin 3-O-(6″-O-galloyl)-β-d-glucopyranoside (4), kaempferol-3-O-β-d-glucopyranoside-7-O-α-l-rhamnopyranoside (5) and kaempferol 3-O-(6″-galloyl)-β-d-glucopyranoside (6). The effects of compounds 1–6 on expression of matrix metalloproteinase-1 (MMP-1) and type-I procollagen were further evaluated. Among them, compound 1 showed potent inhibitory effect on MMP-1 and the increased type-I procollagen synthesis in ultraviolet B-induced human fibroblast. These results suggest that pedunculagin, an ellagitannin, is a potential candidate for the prevention and treatment of skin aging.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010-0022929).

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Authors and Affiliations

  1. Department of Pharmacognosy, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea

    Han Hyuk Kim, Myeong Hwan Oh, Kwang Jun Park, Jun Hyeok Heo & Min Won Lee

  2. Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan, 712-260, Republic of Korea

    Dong Hee Kim

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  1. Han Hyuk Kim
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  2. Dong Hee Kim
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Correspondence to Min Won Lee.

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Kim, H.H., Kim, D.H., Oh, M.H. et al. Inhibition of matrix metalloproteinase-1 and type-I procollagen expression by phenolic compounds isolated from the leaves of Quercus mongolica in ultraviolet-irradiated human fibroblast cells. Arch. Pharm. Res. 38, 11–17 (2015). https://doi.org/10.1007/s12272-014-0329-1

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  • DOI: https://doi.org/10.1007/s12272-014-0329-1

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