Abstract
A capillary electrophoresis method was developed to determine the impurity of etodolac enantiomers. (2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD) was used as a chiral selector and ketoprofen as an internal standard to improve the peak area precision. The seperation of the etodolac enantiomers was achived within 35 min at 15°C and its highest resolution was about 4.0 using phosphate buffer (0.1 M, pH 6.0) with 15 mM HP-β-CD and UV detection at 225 nm with a reference wavelength at 360 nm. This method allowed determination of 0.2% of (R)-(−)-etodolac in (S)-(+)-etodolac and method validation showed adequate linearity over the required range.
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Dung, P.T., Ko, M.Y., Choi, H.J. et al. Determination of enantiomeric impurity of etodolac by capillary electrophoresis using (2-hydroxypropyl)-β-cyclodextrin. Arch. Pharm. Res. 31, 1218–1223 (2008). https://doi.org/10.1007/s12272-001-1292-4
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DOI: https://doi.org/10.1007/s12272-001-1292-4