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Macrophage Polarization in Skin Wound Healing: Progress in Biology and Therapeutics

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Abstract

The morphological and functional barriers caused by pathological scars are extremely painful for patients. Up to now, pathological scar poses a big unmet medical challenge for plastic surgeons and dermatologists worldwide. Macrophage polarization has shown a non-negligible effect on wound healing and scar formation. However, the role of macrophages in wound healing and pathological scar formation is still controversial. To summarize the latest data on probing biological functions of macrophage polarization in wound healing and scar formation and target macrophages in wound healing, we particularly paid attention to studies on different groups of macrophages, the transition among those groups, and modulators regulating the transition process. A comprehensive understanding of macrophage polarization in wound healing is certain to facilitate the development of new and efficient therapeutic modalities for pathological scar.

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Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, the Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Lu Chen  (陈露), Liying Cheng  (程丽英) & Yuguang Zhang  (张余光)

  2. National Research Center for Translational Medicine, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Lu Chen  (陈露) & Jianming Zhang  (张建明)

  3. Research and Development Center, Shanghai Jahwa United Co., Ltd., Shanghai, 201700, China

    Tian Chen  (陈田)

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  1. Lu Chen  (陈露)
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  2. Liying Cheng  (程丽英)
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  3. Tian Chen  (陈田)
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  4. Yuguang Zhang  (张余光)
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  5. Jianming Zhang  (张建明)
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Correspondence to Jianming Zhang  (张建明).

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Foundation item: the National Natural Science Foundation of China (No. 81701907), and the Pujiang Program of SSTC (No. 18PJ1407100)

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Chen, L., Cheng, L., Chen, T. et al. Macrophage Polarization in Skin Wound Healing: Progress in Biology and Therapeutics. J. Shanghai Jiaotong Univ. (Sci.) 27, 264–280 (2022). https://doi.org/10.1007/s12204-021-2276-6

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