Abstract
We report a case of a 58-year-old man who presented with a rapidly growing proliferative lesion on the left lower limb, clinically resembling a soft tissue sarcoma 3 years after renal allograft. There was no evidence of systemic involvement on bone marrow needle aspiration and computed tomography (CT) scans of the chest and abdomen. The lesion turned out to be primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT), as defined in the recent World Health Organization–European Organization for Research and Treatment of Cancer (WHO–EORTC) classification of cutaneous lymphomas by skin biopsy. Immunosuppression reduction, chemotherapy with CHOP regimen and local radiotherapy induced complete remission of the tumor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beynet DP, Wee SA, Horwitz SS, et al. Clinical and pathological features of posttransplantation lymphoproliferative disorders presenting with skin involvement in 4 patients. Arch Dermatol. 2004;140:1140–6.
Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas [published online ahead of print February 3, 2005]. Blood. 2005;105(10):3768–85.
Burg G, Kempf W, Cozzio A, et al. WHO/EORTC classification of cutaneou lymphomas 2005: histological and molecular aspects. J Cutan Pathol. 2005;32(10):647–74.
Slater DN. The new World Health Organization–European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. Br J Dermatol. 2005;153(5):874–80.
Saadat A, Einollahi B, Ahmadzad-Asl MA, et al. Posttransplantation lymphoproliferative disorders in renal transplant recipients: report of over 20 years of experience. Transplant Proc. 2007;39(4):1071–3.
Martín-Gómez MA, Peña M, Cabello M, et al. Posttransplant lymphoproliferative disease: a series of 23 cases. Transplant Proc. 2006;38(8):2448–50.
Caillard S, Lelong C, Pessione F, et al. Post-transplant lymphoproliferative disorders occurring after renal transplantation in adults: report of 230 cases from the French Registry. Am J Transplant. 2006;6(11):2735–42.
Burra P, Buda A, Livi U, et al. Occurrence of post-transplant lymphoproliferative disorders among over thousand adult recipients: any role for hepatitis C infection? Eur J Gastroenterol Hepatol. 2006;18(10):1065–70.
Wasson S, Zafar MN, Best J, et al. Post-transplantation lymphoproliferative disorder in heart and kidney transplant patients: a single-center experience. J Cardiovasc Pharmacol Ther. 2006;11(1):77–83.
Caillard S, Agodoa LY, Bohen EM, et al. Myeloma, Hodgkin disease, and lymphoid leukemia after renal transplantation: characteristics, risk factors and prognosis. Transplantation. 2006;81(6):888–95.
Timurağaoğlu A, Uğur-Bilgin A, Colak D, et al. Posttransplant lymphoproliferative disorders in transplant recipients. Transplant Proc. 2006;38(2):641–5.
Bakker NA, van Imhoff GW, Verschuuren EA, et al. HLA antigens and post renal transplant lymphoproliferative disease: HLA-B matching is critical. Transplantation. 2005;80(5):595–9.
Dharnidharka VR, Stevens G. Risk for post-transplant lymphoproliferative disorder after polyclonal antibody induction in kidney transplantation. Pediatr Transplant. 2005;9(5):622–6.
Jain M, Badwal S, Pandey R, Srivastava A, et al. Post-transplant lymphoproliferative disorders after live donor renal transplantation. Clin Transplant. 2005;19(5):668–73.
Faull RJ, Hollett P, McDonald SP. Lymphoproliferative disease after renal transplantation in Australia and New Zealand. Transplantation. 2005;80(2):193–7.
Bakker NA, van Imhoff GW, Verschuuren EA, et al. Early onset post-transplant lymphoproliferative disease is associated with allograft localization. Clin Transplant. 2005;19(3):327–34.
Hoefnagel JJ, Vermeer MH, Jansen PM, et al. Primary cutaneous marginal zone B-cell lymphoma: clinical and therapeutic features in 50 cases. Arch Dermatol. 2005;141(9):1139–45.
Fink-Puches R, Zenahlik P, Back B, et al. Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients. Blood. 2002;99(3):800–5.
Hembury TA, Lee B, Gascoyne RD, Macpherson N, Yang B, House N, et al. Primary cutaneous diffuse large B-cell lymphoma: A clinicopathologic study of 15 cases. Am J Clin Pathol. 2002;117:574–80.
Grange F, Bekkenk MW, Wechsler J, Meijer CJ, Cerroni L, Bernengo M, et al. Prognostic factors in primary cutaneous large B-cell lymphomas: A European multicentric study. J Clin Oncol. 2001;19:3602–10.
Grange F, Beylot-Barry M, Courville P, et al. Primary cutaneous diffuse large B-cell lymphoma, leg type—clinicopathologic features and prognostic analysis in 60 cases. Arch Dermatol. 143(9):1144–50.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Zhao, J., Han, B., Shen, T. et al. Primary cutaneous diffuse large B-cell lymphoma (leg type) after renal allograft: case report and review of the literature. Int J Hematol 89, 113–117 (2009). https://doi.org/10.1007/s12185-008-0201-5
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12185-008-0201-5