Abstract
The development of a fast and reliable screening method for the determination of tetracycline residues in milk is described and compared to high-performance liquid chromatography. The method is based on europium-sensitized luminescence: The emissive properties of the lanthanide cation are used as a fingerprint of europium (III) complexation with tetracycline. The optimization of the extraction and purification procedures provided a simple and convenient route to prepare stable tetracycline samples that can safely resist freezing cycles. The method is validated for the first time in milk matrix: The results show that accuracy and precision of the method meet complaints with the criteria of the Commission Decision 2002/657/EC. The proposed method has a false compliant rate (β error) lower than 5%.
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Acknowledgments
The work was supported by the Ministero della Salute (Ricerca Finalizzata IZSLT 09/02) and CSGI/CNR-FUSINT 2006. Sara Morandi thanks the Italian Ministero della Salute and CSGI (Consorzio Sistemi a Grande Interfase) for partial financial support.
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Morandi, S., Focardi, C., Nocentini, M. et al. Development and Validation of Europium-Sensitized Luminescence (ESL) Method for the Determination of Tetracycline Residues in Milk. Food Anal. Methods 2, 271–281 (2009). https://doi.org/10.1007/s12161-008-9066-8
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DOI: https://doi.org/10.1007/s12161-008-9066-8