Abstract
A critical feature of all cellular processes is the ability to control the rate of gene or protein expression and metabolic flux in changing environments through regulatory feedback. We review the many ways that regulation is represented through causal, logical, and dynamical components. Formalizing the nature of these components promotes effective comparison among distinct regulatory networks and provides a common framework for the potential design and control of regulatory systems in synthetic biology.
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Acknowledgements
The authors thank the John Templeton Foundation for funding this research with the Grant “Origins and Evolution of Regulation in Biological Systems”—ID: 24332. The opinions expressed in this publication are those of the author(s) and do not necessarily reflect the views of the John Templeton Foundation. This work was partially funded by the the German Federal Ministry of Science (0316165C) as part of the e:Bio initiative.
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D. C. Krakauer, L. Müller, S. J. Prohaska and P. F. Stadler contributed equally.
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Krakauer, D.C., Müller, L., Prohaska, S.J. et al. Design specifications for cellular regulation. Theory Biosci. 135, 231–240 (2016). https://doi.org/10.1007/s12064-016-0239-5
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DOI: https://doi.org/10.1007/s12064-016-0239-5