Abstract
Here, we presented a case of carcinosarcoma of the pancreas in a 53-year-old woman. The carcinosarcoma was in the head of pancreas. She underwent a pancreaticoduodenectomy. The tumor was grossly yellowish-whitish. Histologic evaluation of the tumor revealed 2 elements separated from each other. One component was conventional pancreatic ductal adenocarcinoma, and the other component showed sarcomatous growth pattern composed of pleomorphic spindle cells. Immunohistochemically, the adenocarcinoma component was reactive for antibodies to cytokeratin 18 and epithelial membrane antigen. The sarcomatous component was reactive for smooth muscle antibody. These findings led to a diagnosis of pancreatic carcinosarcoma. The patient was treated with gemcitabine, adriamycin, and cisplatin after the operation. Although previously reported patients with pancreatic carcinosarcoma showed a very poor outcome, this patient has remained free of recurrence for 20 months, which is the longest recurrence-free survival time recorded for this type of cancer. This treatment plan may be a feasible option.
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References
Millis JM, Chang B, Zinner MJ, Barsky SH. Malignant mixed tumor (carcinosarcoma) of the pancreas: a case report supporting organ-induced differentiation of malignancy. Surgery. 1994;115(1):132–7.
Watanabe M, Miura H, Inoue H, Uzuki M, Noda Y, Fujita N, et al. Mixed osteoclastic/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: histochemical and immunohistochemical study with review of the literature. Pancreas. 1997;15(2):201–8.
Yamazaki K. A unique pancreatic ductal adenocarcinoma with carcinosarcomatous histology, immunohistochemical distribution of hCG-beta, and the elevation of serum alpha-feto-protein. J Submicrosc Cytol Pathol. 2003;35(4):343–9.
Nai GA, Amico E, Gimenez VR, Guilmar M. Osteoclast-like giant cell tumor of the pancreas associated with mucus-secreting adenocarcinoma—case report and discussion of the histogenesis. Pancreatology. 2005;5(2–3):279–84.
Bloomston M, Chanona-Vilchis J, Ellison EC, Ramirez NC, Frankel WL. Carcinosarcoma of the pancreas arising in a mucinous cystic neoplasm. Am Surg. 2006;72(4):351–5.
van den Berg W, Tascilar M, Offerhaus GJA, Albores-Saavedra J, Wenig BM, Hruban RH, et al. Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. Mod Pathol. 2000;13(1):86–91.
Shen ZL, Wang S, Ye YJ, Wang YL, Sun KK, Yang XD, et al. Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: is there a good prognosis with the complete resection? Eur J Cancer Care (Engl). 2009.
Barkatullah SA, Deziel DJ, Jakate SM, Kluskens L, Komanduri S. Pancreatic carcinosarcoma with unique triphasic histological pattern. Pancreas. 2005;31(3):291–2.
Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E, et al. Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma. Pathol Int. 2008;58(10):672–7.
Gelos M, Behringer D, Philippou S, Mann B. Pancreatic carcinosarcoma. Case report of multimodal therapy and review of the literature. JOP. 2008;9(1):50–5.
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Zhu, WY., Liu, TG. & Zhu, H. Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review. Med Oncol 29, 140–143 (2012). https://doi.org/10.1007/s12032-010-9804-9
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DOI: https://doi.org/10.1007/s12032-010-9804-9