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Primary Diffuse Large B-cell Lymphoma of Ampulla of Vater: A Rare Case Report

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Abstract

Introduction

Primary lymphomas of the ampulla of Vater are extremely rare. Among these most frequent are follicular lymphomas followed by mucosa-associated lymphoid tissue-type lymphoma.

Case Report

We report a case of a 36-year-old female diagnosed with diffuse large B-cell lymphoma (DLBCL) of the ampulla of Vater. Endoscopic biopsy was non-diagnostic. Whipple’s resection was performed. The patient was given six cycles of chemotherapy. One year later, the patient developed recurrence at the anastomotic site and again treated with combination chemotherapy. Patient is doing well after 2 years of initial surgery.

Discussion

Tumors of the ampulla of Vater are included in the pancreaticobiliary group of neoplasms; in some instances, it is almost impossible to ascertain the exact origin of the tumor anatomically. The patients of primary lymphoma of the ampulla of Vater may have a varied clinical presentation or may be completely asymptomatic and detected during routine medical check-ups for gastric cancer screening.

Conclusion

We present a rare case of primary DLBCL of the periampullary region. Due to the rarity of these lesions, their ability to masquerade as periampullary carcinomas, and the fact that these tumors show a good response to chemotherapy, an early diagnosis is desirable.

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Acknowledgments

The authors wish to express their thanks to Dr. P.M. Shah, Honorary Director, Dr. K.M. Patel, Dr. S.N. Shukla, and Dr. R.I. Dave, Deputy Directors of The Gujarat Cancer & Research institute for allowing us to publish this case report.

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Authors and Affiliations

  1. Department of Pathology, Gujarat Cancer and Research Institute, M.P. Shah Cancer Hospital, Room No. 412, NCH Campus, Asarwa, Ahmedabad, Gujarat, 380016, India

    Priti Trivedi, Anuja Gupta & Sunil Pasricha

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  1. Priti Trivedi
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  2. Anuja Gupta
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  3. Sunil Pasricha
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Correspondence to Priti Trivedi.

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Trivedi, P., Gupta, A. & Pasricha, S. Primary Diffuse Large B-cell Lymphoma of Ampulla of Vater: A Rare Case Report. J Gastrointest Canc 43, 340–343 (2012). https://doi.org/10.1007/s12029-010-9202-8

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  • DOI: https://doi.org/10.1007/s12029-010-9202-8

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