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Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway

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Abstract

Mechanical loading is known to promote osteocyte survival, whereas glucocorticoid treatment results in osteocyte apoptosis. Here, we report that BMP-7, which was secreted by osteocyte in response to mechanical loading, exerts anti-apoptotic effect against dexamethasone-induced apoptosis of osteocytes. We further show that the anti-apoptotic effect of BMP-7 is mainly mediated through receptor BMPR2 and is associated with the activation of PI3K/AKT/GSK3β pathway.

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Authors and Affiliations

  1. Department of Orthopedics, Xuzhou Central Hospital, 199 South Jiefang Rd., Xuzhou, 221009, Jiangsu, China

    Zhaohong Wang

  2. Department of Bone Trauma, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China

    Jun Guo

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  1. Zhaohong Wang
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  2. Jun Guo
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Correspondence to Jun Guo.

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Wang, Z., Guo, J. Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway. Cell Biochem Biophys 67, 567–574 (2013). https://doi.org/10.1007/s12013-013-9543-6

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  • DOI: https://doi.org/10.1007/s12013-013-9543-6

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