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Blood Cadmium Concentrations in Women with Ectopic Pregnancy

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Abstract

The purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 μg/l (interquartile range [IQR] 0.00–0.71) in the women with ectopic pregnancies and 0.34 μg/l (IQR 0.09–0.59) in the controls. There was no significant association between blood cadmium levels and ectopic pregnancy.

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References

  1. Mandra M, Horne AW (2014) Ectopic pregnancy. Obstet Gynecol Reprod 24:7

    Google Scholar 

  2. Creanga AA, Shapiro-Mendoza CK, Bish CL, Zane S, Berg CJ, Callafhan WM (2011) Trends in ectopic pregnancy mortality in the United States:1980–2007. Obstet Gynecol 117:837–843

    Article  PubMed  Google Scholar 

  3. Karaer A, Avsar FA, Batioglu S (2006) Risk factors for ectopic pregnancy: a case-control study. ANZJOG 46:521–527

    PubMed  Google Scholar 

  4. Karaer A, Mert I, Cavkaytar S, Batioglu S (2013) Serological investigation of the role of selected sexually transmitted infections in the aetiology of ectopic pregnancy. Eur J Contracept Reprod Health Care 18:68–74

    Article  PubMed  Google Scholar 

  5. Bouyer J, Coste J, Shojaei T, Pouly JL, Fernandez H, Gerbaud L, Job-Spira N (2003) Risk factors for ectopic pregnancy: a comprehensive analysis on a large case-control study, population-based study in France. Am J Epidemiol 157:185–194

    Article  PubMed  Google Scholar 

  6. Horne AW, Brown JK, Nio-Kobayashi J, Abidin HBZ, Adin ZEHA, Boswell L, Burgess S, Lee KF, Duncan WC (2014) The association between smoking and ectopic pregnancy: why nicotine is bad for your fallopian tube. PLoS One 9:89400

    Article  CAS  Google Scholar 

  7. Talbot P, Riveles K (2005) Smoking and reproduction: the oviducts as a target of cigarette smoke. Reprod Biol Endocrinol 3:52

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Jarup L, Akesson A (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238:201–208

    Article  PubMed  CAS  Google Scholar 

  9. Satarug S, Baker JR, Urbenjapol S, Haswell-Elkins M, Reilly PE, Williams DJ et al (2003) A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett 137:65–83

    Article  PubMed  CAS  Google Scholar 

  10. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012) Heavy metals toxicity and environment. EXS 101:133–164

    PubMed  PubMed Central  Google Scholar 

  11. Gonzales-Reimers E, Martin-Gonzalez C, Galindo-Martin L, Aleman-Valls MR, Velasco-Vazquez J, Arnay-de-la-Rosa M et al (2014) Lead, cadmium and zinc in hair samples: relationship with dietary habits and urban environment. Biol Trace Elem Res 157(3):205–210

    Article  CAS  Google Scholar 

  12. Thompson J, Bannigan J (2008) Cadmium toxic effects on the reproductive system and the embryo. Reprod Toxicol 25:304–315

    Article  PubMed  CAS  Google Scholar 

  13. Jarup L, Berglund M, Elinder CG, Nordberg G, Vanter M (1998) Health effects of cadmium exposure: a review of the literature and a risk estimate. Scand J Work Environ Health 24:1–51

    Article  PubMed  Google Scholar 

  14. Shaw JLV, Dey SK, Critchley HOD, Horne AW (2010) Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update 16:432–444

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Haki K, Kadir S, Yaflar A (2003) Effects of cadmium on uterine contractions in different species in vitro. Turk J Vet Anim Sci 27:529–534

    Google Scholar 

  16. Niwa A, Suzuki A (1982) Effects of cadmium on the tension of isolated rat aorta: a possible mechanism for cadmium induced hypertension. J Toxicol Sci 7:51–60

    Article  PubMed  CAS  Google Scholar 

  17. Sivalingam VN, Duncan WC, Kirk E, Shephard LA, Horne AW (2011) Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care 37:231–240

    Article  PubMed  PubMed Central  Google Scholar 

  18. Matusiewicz H (2003) Wet digestion methods. In: Mester Z, Sturgeon R (eds) Comprehensive analytical chemistry. Volume 41: sample preparation for trace element analysis. Elsevier, Netherlands, pp 193–233

    Chapter  Google Scholar 

  19. Kebbekulus BB (2003) Preparation of samples for metals analysis. In: Mitra S (ed) Sample Preparation Techniques in Analytical Chemistry. Wiley Interscience, Canada, pp 227–270

    Chapter  Google Scholar 

  20. Sharma T, Dev Banerjee B, Yadav CS, Gupta P, Sharma A (2014) Heavy metal levels in adolescent and maternal blood: association with risk of hypospadias. ISRN Pediatr 4:714234

    Google Scholar 

  21. Borgerding M, Klus H (2005) Analysis of complex mixtures: cigarette smoke. Exp Toxicol Pathol 57:43–73

    Article  PubMed  CAS  Google Scholar 

  22. Berglund M, Lindberg AL, Rahman M et al (2011) Gender and age differences in mixed metal exposure and urinary excretion. Environ Res 111(8):1271–1279

    Article  PubMed  CAS  Google Scholar 

  23. Nishijo M, Satarug S, Honda R, Tsuritani I, Aoshima K (2004) The gender differences in health effects of environmental cadmium exposure and potential mechanisms. Mol Cell Biochem 255(1–2):87–92

  24. Demirezen D, Aksoy A (2006) Heavy metal levels in vegetables in Turkey are within safe limits for Cu, Zn, Ni, and exceeded for Cd and Pb. J Food Quality 29:252–265

    Article  CAS  Google Scholar 

  25. Güçer Ş, Demir M, Karagözler AE, Karakaplan M (1992) Atmospheric distribution of some trace metals in Malatya. Industrial Air Pollution 31:195–201

  26. Ozmen H, Kulahci F, Cukurovali A, Dogru M (2004) Concentrations of heavy metal and radioactivity in surface water and sediment of Hazar Lake, Elazığ, Turkey. Chemosphere 55:401–408

    Article  PubMed  CAS  Google Scholar 

  27. Agency for Toxic Substances and Disease Registry (2017) Priority list of hazardous substances. Available from : www.atsdr.cdc.gov/spl

  28. Takiguchi M, Yoshihara S (2006) New aspects of cadmium as endocrine disruptor. Environ Sci 13(2):107–116

    PubMed  CAS  Google Scholar 

  29. Piasek M, Laskey JW (1999) Effect of in vitro cadmium exposure on ovarian steroidogenesis in rats. J Appl Toxicol 19:211–217

  30. Zenzes NT, Krishnan S, Krishnan B, Zhang H, Casper RF (1995) Cadmium accumulation in follicular fluid of women in vitro fertilization-embryo transfer is higher in smokers. Fertility Sterility 64:559–603

    Article  Google Scholar 

  31. Varga B, Zsolnai B, Paksy K, Nuray M, Ungvary G (1993) Age dependent accumulation of cadmium in the human ovary. Reprod Toxicol 7:225–228

    Article  PubMed  CAS  Google Scholar 

  32. Vrsanska S, Nagyova E, Mlynarcikova A, Fickova M, Kolena J (2003) Components of cigarette smoke inhibit expansion of oocyte-cumulus complexes from porcine follicles. Physiol Res 52:383–387

    PubMed  CAS  Google Scholar 

  33. Paksy K, Varga B, Náray M, Olajos F, Folly G (1992) Altered ovarian progesterone secretion induced by cadmium fails to interfere with embryo transport in the oviduct of the rat. Reprod Toxicol 6:77–83

    Article  PubMed  CAS  Google Scholar 

  34. Willers S, Shütz A, Attewell R, Skerfving S (1988) Relation between lead and cadmium in blood and the involuntary smoking of children. Scan J Work Environ Health 14:385–389

    Article  CAS  Google Scholar 

  35. Judith S, Alex M, Ruth A, Joseph R (1996) Biological monitoring of exposure to cadmium, a human carcinogen, as a result of active and passive smoking. J Occupat Envir Med 38:1220–1227

    Article  Google Scholar 

  36. Shaham J, Green M, Ribak J (1992) Passive smoking: clinical aspects and workers’ awareness. Harefuah 123:53–57

    PubMed  CAS  Google Scholar 

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Funding

This work was funded by the Scientific Research Projects Unit of Inonu University.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Departments of Obstetrics and Gynecology, Inonu University, School of Medicine, 44315, Malatya, Turkey

    Abdullah Karaer & Gorkem Tuncay

  2. Departments of Obstetrics and Gynecology, Malatya State Hospital, Malatya, Turkey

    Emrullah Tanrikut

  3. Laboratory of Atomic Absorption Spectrometry, Scientific and Technological Research Center, Inonu University, Malatya, Turkey

    Onur Ozgul

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  1. Abdullah Karaer
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  2. Gorkem Tuncay
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  3. Emrullah Tanrikut
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  4. Onur Ozgul
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Correspondence to Abdullah Karaer.

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Karaer, A., Tuncay, G., Tanrikut, E. et al. Blood Cadmium Concentrations in Women with Ectopic Pregnancy. Biol Trace Elem Res 184, 42–46 (2018). https://doi.org/10.1007/s12011-017-1179-8

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  • DOI: https://doi.org/10.1007/s12011-017-1179-8

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