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Effects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats

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Abstract

Ellagic acid (EA) is a natural polyphenolic compound. Although, modulator effects of EA on copper (Cu) and zinc (Zn) levels in some liver diseases have been reported in experimental animals, its effects in obstructive jaundice (OJ) has not been clarified. We aimed to evaluate potential effects of EA on Cu and Zn levels in liver and serum of cholestatic rats. Forty Wistar albino rats were equally divided into four groups. First group was used as controls. Second group received EA (60 mg−1 kg−1 day−1) for 8 days. Third was OJ group, and fourth group was OJ plus EA group. After 8 days, blood and liver samples were obtained. Higher serum and liver Cu and lower serum and liver Zn levels were found in OJ group (p < 0.05) compared with other groups. However, these differences reached to significant levels for Cu in serum and for Zn in lever. Higher serum copper levels were decreased, and lower liver Zn levels were increased by EA treatment in cholestatic rats (p < 0.05). Also, higher Cu/Zn ratio in OJ group was decreased by EA treatment both in liver (p < 0.05) and in serum (p < 0.05). Significantly higher serum bilirubin, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase values were found in OJ and OJ + EA groups compared with the control and EA groups (p < 0.05). In conclusion, result of the current study indicated that ellagic acid has modulator effects on Cu and Zn levels in liver and serum of cholestatic rats.

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Abbreviations

ALP:

Alkaline phosphatase

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

Cu:

Copper

EA:

Ellagic acid

OJ:

Obstructive jaundice

TB:

Total bilirubin

Zn:

Zinc

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Authors and Affiliations

  1. Department of General Surgery, Medical School, Dicle University, Yenişehir, 21280, Diyarbakir, Turkey

    Metehan Gümüş, Murat Kapan, Abdullah Böyük, Akın Önder & Mustafa Aldemir

  2. Department of Biochemistry, Obstetrics and Pediatrics State Hospital, Diyarbakir, Turkey

    Hatice Yüksel

  3. Department of Biochemistry, Medical School, Dicle University, Diyarbakir, Turkey

    Osman Evliyaoğlu

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  1. Metehan Gümüş
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  2. Hatice Yüksel
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  4. Murat Kapan
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Correspondence to Metehan Gümüş.

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Gümüş, M., Yüksel, H., Evliyaoğlu, O. et al. Effects of Ellagic Acid on Copper, Zinc, and Biochemical Values in Serum and Liver of Experimental Cholestatic Rats. Biol Trace Elem Res 143, 386–393 (2011). https://doi.org/10.1007/s12011-010-8863-2

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  • DOI: https://doi.org/10.1007/s12011-010-8863-2

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