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The Removal of the Bereavement Exclusion in the DSM-5: Exploring the Evidence

  • Mood Disorders (SM Strakowski, Section Editor)
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Abstract

Since 1980, the DSM-III and its various iterations through the DSM-IV-TR have systematically excluded individuals from the diagnosis of major depressive disorder if symptoms began within months after the death of a loved one (2 months in DSM-IV), unless the depressive syndrome was ‘severely’ impairing and/or accompanied by specific features. This criterion became known as the ‘bereavement exclusion’. No other adverse life events were noted to negate the diagnosis of major depressive disorder if all other symptomatic, duration, severity and distress/impairment criteria were met. However, studies since the inception of the bereavement exclusion have shown that depressive syndromes occurring after bereavement share many of the same features as other, non-bereavement related depressions, tend to be chronic and/or recurrent if left untreated, interfere with the resolution of grief, and respond to treatment. Furthermore, the bereavement exclusion has had the unintended consequence of suggesting that grief should end in only 2 months, or that grief and major depressive disorder cannot co-occur. To prevent the denial of diagnosis and the consideration of sometimes much needed care, even after bereavement or other significant losses, the DSM-5 no longer contains the bereavement exclusion. Instead, the DSM-5 now permits the diagnosis of major depressive disorder after and during bereavement and includes a note and a comprehensive footnote in the major depressive episode criteria set to guide clinicians in making the diagnosis in this context. The decision to make this change was widely and publically debated and remains controversial. This article reports on the rationale for this decision and the way the DSM-5 now addresses the challenges of diagnosing major depressive disorder in the context of someone grieving the loss of a loved one.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. • First MB, Pies RW, Zisook S. Depression or bereavement? Defining the distinction. Medscape Psychiatry & Mental Health 2011. Available from: http://www.medscape.com/viewarticle/740333. Accessed 11 May 2011. Virtual debate regarding the removal of the bereavement exclusion from DSM-5.

  2. • First MB. DSM-5 proposals for mood disorders: a cost-benefit analysis. Curr Opin Psychiatry. 2011;24:1–9. Cost-benefit analysis for proposed changed to the DSM-5 Mood Disorders Criteria, including the removal of the bereavement exclusion.

    Article  PubMed  Google Scholar 

  3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-III). American Psychiatric Association: Washington, DC. 1980.

  4. • Wakefield JC, Schmitz MF, Baer JC. Did narrowing the major depression bereavement exclusion from DSM-III-R to DSM-IV increase validity?: evidence from the National Comorbidity Survey. J Nerv Ment Dis. 2011;199(2):66–73. Epidemiologic study evaluating the relationship between duration and severity in bereavement-related depression.

    Article  PubMed  Google Scholar 

  5. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed. text revision. Washington, DC: American Psychiatric Association; 2000.

  6. Clayton P, Desmarais L, Winokur G. A study of normal bereavement. Am J Psychiatry. 1968;125(2):168–78.

    PubMed  CAS  Google Scholar 

  7. Clayton PJ, Halikes JA, Maurice WL. The bereavement of the widowed. Dis Nerv Syst. 1971;32(9):597–604.

    PubMed  CAS  Google Scholar 

  8. Clayton PJ, Halikas JA, Maurice WL. The depression of widowhood. Brit J Psychiatry. 1972;120(554):71–7.

    Article  CAS  Google Scholar 

  9. Bornstein PE, Clayton PJ, Halikas JA, et al. The depression of widowhood after thirteen months. Brit J Psychiatry. 1973;122(570):561–6.

    Article  CAS  Google Scholar 

  10. Clayton PJ, Herjanic M, Murphy GE, et al. Mourning and depression: their similarities and differences. Can Psychiatr Assoc J. 1974;19(3):309–12.

    PubMed  CAS  Google Scholar 

  11. Clayton PJ, Darvish HS. Course of depressive symptoms following the stress of bereavement. In: Barrett JE, Rose RM, Klerman GL, editors. Stress and mental disorder. New York: Raven Press; 1979. p. 121–36.

    Google Scholar 

  12. • Hensley PL, Clayton PJ. Why the bereavement exclusion was introduced in DSM-III. Psychiatric Annals. 2013;43(6):256–60. Review article outlining the first methodologically rigorous, longitudinal studies of bereavement and depression that led to the adoption of bereavement exclusion in DSM-III.

    Article  Google Scholar 

  13. Clayton PJ. Bereavement and depression. J Clin Psychiatry. 1990;51:34–8.

    PubMed  Google Scholar 

  14. • Gilman SE, Breslau J, Trinh NH, Fava M, Murphy JM, Smoller JW. Bereavement and the diagnosis of major depressive episode in the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2012;73(2):208–15. Epidemiologic study assessing the validity of the bereavement exclusion by comparing individuals with bereavement-excluded depressive episodes, complicated bereavement, and non-loss related MDE.

    Article  PubMed  Google Scholar 

  15. Wakefield JC, Schmitz MF, First MB, Horwitz AV. Extending the bereavement exclusion for major depression to other losses: evidence from the National Comorbidity Survey. Arch Gen Psychiatry. 2007;64(4):433–40.

    Article  PubMed  Google Scholar 

  16. Kendler KS, Myers J, Zisook S. Does bereavement-related major depression differ from major depression associated with other stressful life events? Am J Psychiatry. 2008;165(11):1449–55.

    Article  PubMed  Google Scholar 

  17. Ayuso-Mateos JL, Vazquez-Barquero JL, Dowrick C, Lehtinen V, Dalgard OS, Casey P, et al. Depressive disorders in Europe: prevalence figures from the ODIN study. Br J Psychiatry. 2001;179:308–16.

    Article  PubMed  CAS  Google Scholar 

  18. • Zisook S, Corruble E, Duan N, Iglewicz A, Karam EG, Lanouette N, et al. The bereavement exclusion and DSM-5. Depress Anxiety. 2012;29(5):425–43. Critical review article evaluating the validity of the bereavement exclusion for DSM-V.

    Article  PubMed  Google Scholar 

  19. • Iglewicz A, Seay K, Vigeant S, Kaur Jouhal S, Zisook S. The bereavement exclusion: the truth between pathology and politics. Psychiatr Ann. 2013;43(6):261–6. Critical review article outlining the arguments for and against the elimination of the bereavement exclusion from DSM-V.

    Article  Google Scholar 

  20. • Pies R. From context to phenomenology in grief versus major depression. Psychiatr Ann. 2013;43(6):286–90. Essay comparing how grief and MDD are experienced.

    Article  Google Scholar 

  21. Zisook S, Shear K. Grief and bereavement: what psychiatrists need to know. World Psychiatry. 2009;8(2):67–74.

    PubMed  Google Scholar 

  22. • Zisook S, Reynolds 3rd CF, Pies R, Simon N, Lebowitz B, Madowitz J, et al. Bereavement, complicated grief, and DSM, part 1: depression. J Clin Psychiatry. 2010;71(7):955–6. Brief article evaluating the validity of the bereavement exclusion and bereavement V code in DSM-IV-TR, as compared to ICD-10.

    Article  PubMed  Google Scholar 

  23. • Lamb K, Pies R, Zisook S. The bereavement exclusion for the diagnosis of major depression: to be, or not to be. Psychiatry (Edgmont). 2010;7(7):19–25. Review paper evaluating the validity of the bereavement exclusion for the diagnosis of MDD. The authors conclude that the exclusion is not supported by the best available data and they propose revisions for DSM-5.

    Google Scholar 

  24. Pies RW. Depression and the pitfalls of causality: implications for DSM-V. J Affect Disord. 2009;116(1–2):1–3.

    Article  PubMed  Google Scholar 

  25. Bonanno GA, Kaltman S. The varieties of grief experience. Clin Psychol Rev. 2001;21(5):705–34.

    Article  PubMed  CAS  Google Scholar 

  26. Bonanno GA, Moskowitz JT, Papa A, Folkman S. Resilience to loss in bereaved spouses, bereaved parents, and bereaved gay men. J Pers Soc Psychol. 2005;88(5):827–43.

    Article  PubMed  Google Scholar 

  27. Freud S. Mourning and Melancholia. The Standard Edition of the Complete Psychological Works of Sigmund Freud, XIV (1914–1916): On the History of the Psycho-Analytic Movement, papers on Metapsychology and Other Works1917. p. 237–58.

  28. Wakefield JC. Should prolonged grief be reclassified as a mental disorder in DSM-5?: reconsidering the empirical and conceptual arguments for complicated grief disorder. J Nerv Ment Dis. 2012;200(6):499–511.

    Article  PubMed  Google Scholar 

  29. • Frances A, Pies R, Zisook S. DSM5 and the medicalization of grief: two perspectives. PsychiatrTimes. 2010;27(5):46–7. Essay outlining bereavement concerns with DSM-5 and the medicalization of grief.

    Google Scholar 

  30. Doka KJ. Grief and the DSM: A Brief Q&A. Huffington Post; 2013; Available from: http://www.huffingtonpost.com/kenneth-j-doka/grief-and-the-dsm_b_3340216.html.

  31. • Span P. Grief over new depression diagnosis. New York Times; 2013; Available from: http://newoldage.blogs.nytimes.com/2013/01/24/grief-over-new-depression-diagnosis/?_r=1. Blog post discussing the controversial removal of the DSM-5 bereavement exclusion.

  32. Lesse S. The masked depression syndrome–results of a seventeen-year clinical study. Am J Psychother. 1983;37(4):456–75.

    PubMed  CAS  Google Scholar 

  33. Zisook S, Shuchter SR. Time course of spousal bereavement. Gen Hosp Psychiatry. 1985;7(2):95–100.

    Article  PubMed  CAS  Google Scholar 

  34. Kessler RC. The effects of stressful life events on depression. Annu Rev Psychol. 1997;48:191.

    Article  PubMed  CAS  Google Scholar 

  35. Kendler KS, Karkowski LM, Prescott CA. Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry. 1999;156(6):837.

    PubMed  CAS  Google Scholar 

  36. Spiegel D. Cancer and depression. Br J Psychiatry. 1996;168:109.

    Google Scholar 

  37. Narushima K, Robinson RG. Stroke-related depression. Curr Atheroscler Rep. 2002;4:296–303.

    Article  PubMed  Google Scholar 

  38. • Sheth A. Dementia and depression. J Assoc Physicians India. 2011;59. Brief editorial outlining the importance of assessing cognitive impairment in depressed older adult populations.

  39. • Mostofsky E, Maclure M, Sherwood JB, Tofler GH, Muller JE, Mittleman MA. Risk of acute myocardial infarction after the death of a significant person in one's life: the Determinants of Myocardial Infarction Onset Study. Circulation. 2012;125(3):491–6. Secondary analysis of a Mayocardial infarction study that found that grief was associated with an acutely increased risk of myocardial infarction in the days following the loss, particularly for those with high cardiovascular risk.

    Article  PubMed  Google Scholar 

  40. Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M. Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003;157(5):415–23.

    Article  PubMed  Google Scholar 

  41. Hirschfeld RM, Klerman GL, Andreasen NC, Clayton PJ, Keller MB. Situational major depressive disorder. Arch Gen Psychiatry. 1985;42(11):1109–14.

    Article  PubMed  CAS  Google Scholar 

  42. Winokur G. The validity of neurotic-reactive depression. New data and reappraisal. Arch Gen Psychiatry. 1985;42(11):1116–22.

    Article  PubMed  CAS  Google Scholar 

  43. Kendler KS, Eaves LJ, Walters EE, Neale MC, Heath AC, Kessler RC. The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Arch Gen Psychiatry. 1996;53(5):391–9.

    Article  PubMed  CAS  Google Scholar 

  44. Karam EG, Tabet CC, Alam D, Shamseddeen W, Chatila Y, Mneimneh Z, et al. Bereavement related and non-bereavement related depressions: a comparative field study. J Affect Disord. 2009;112(1–3):102–10.

    Article  PubMed  Google Scholar 

  45. • Kessing LV, Bukh JD, Bock C, Vinberg M, Gether U. Does bereavement-related first episode depression differ from other kinds of first depressions? Soc Psychiatry Psychiatr Epidemiol. 2010;45(8):801–8. Empirical study comparing individuals with bereavement-related first episode of depression to individuals with non-bereavement-related first episode of depression. Results found that bereavement related first episode of depression does not differ from other kinds of first depression.

    Article  PubMed  Google Scholar 

  46. • Corruble E. Study results and the discriminant validity of DSM-IV bereavement exclusion. Psychiatr Ann. 2013;43(6):272–5. Summarizes data from a series of large, naturalistic, case-controlled studies of individuals seeking treatment for depression. Results suggest that the bereavement exclusion is confusing and often misused by clinicians.

    Article  Google Scholar 

  47. Wakefield JC, First MB. Validity of the bereavement exclusion to major depression: does the empirical evidence support the proposal to eliminate the exclusion in DSM-5? World Psychiatry. 2012;11(1):3–10.

    Article  PubMed  Google Scholar 

  48. • Wakefield JC, Schmitz MF. Recurrence of depression after bereavement-related depression: evidence for the validity of DSM-IV bereavement exclusion from the Epidemiologic Catchment Area Study. J Nerv Ment Dis. 2012;200(6):480–5. Epidemiologic study assessing the validity of the bereavement exclusion by comparing depression recurrence rates for individuals with (1) no history of depressive disorder, (2) excludable bereavement-related depression, (3) brief-episode depression, and (4) non-brief lifetime depression.

    Article  PubMed  Google Scholar 

  49. Wakefield JC, Schmitz MF. Normal vs. disordered bereavement-related depression: are the differences real or tautological? Acta Psychiatr Scand. 2013;127(2):159–68.

    Article  PubMed  CAS  Google Scholar 

  50. • Mojtabai R. Bereavement-related depressive episodes: characteristics, 3-year course, and implications for the DSM-5. Arch Gen Psychiatry. 2011;68(9):920–8. Epidemiologic study comparing the demographic and psychiatric characteristics of participants with bereavement-related depressive episodes and other types of depressive episodes.

    Article  PubMed  Google Scholar 

  51. • Paksarian D, Mojtabai R. Distinguishing bereavement from depression in DSM-5: evidence from longitudinal epidemiologic surveys. Psychiatr Ann. 2013;43(6):276–82. Secondary analysis of three recent studies by Wakefield and Schmitz (2012), Gilman et al. (2012), and Mojtabai (2011) demonstrating low recurrence rates of depression for bereavement excluded MDEs.

    Article  Google Scholar 

  52. Zisook S, Kendler KS. Is bereavement-related depression different than non-bereavement-related depression? Psychol Med. 2007;37(6):779–94.

    Article  PubMed  Google Scholar 

  53. Zisook S, Shear K, Kendler KS. Validity of the bereavement exclusion criterion for the diagnosis of major depressive episode. World Psychiatry. 2007;6(2):102–7.

    PubMed  Google Scholar 

  54. Zisook S, Shuchter SR. Uncomplicated bereavement. J Clin Psychiatry. 1993;54(10):365–72.

    PubMed  CAS  Google Scholar 

  55. Zisook S, Shuchter SR. Major depression associated with widowhood. Am J Geriatr Psychiatry. 1993;1(4):316–26.

    Article  Google Scholar 

  56. • Shear MK, Simon N, Wall M, Zisook S, Neimeyer R, Duan N, et al. Complicated grief and related bereavement issues for DSM-5. Depress Anxiety. 2011;28(2):103–17. Review paper evaluating bereavement-related issues and complicated grief for the DSM-5.

    Article  PubMed  Google Scholar 

  57. Corruble E, Chouinard VA, Letierce A, Gorwood PA, Chouinard G. Is DSM-IV bereavement exclusion for major depressive episode relevant to severity and pattern of symptoms? J Clin Psychiatry. 2009;70(8):1091–7.

    Article  PubMed  Google Scholar 

  58. • Corruble E, Falissard B, Gorwood P. Is DSM-IV bereavement exclusion for major depression relevant to treatment response? A case–control, prospective study. J Clin Psychiatry. 2011;72(7):898–902. A case-controlled, prospective study evaluating the validity of the bereavement exclusion by comparing treatment response for those with bereavement-related depression to those with non-bereavement-related depression.

    Article  PubMed  Google Scholar 

  59. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Publishing; 2013.

    Google Scholar 

  60. • Kupfer D. DSM-5 approved by the APA board. eMPR; 2012; Available from: http://www.empr.com/dsm-5-approved-by-the-apa-board/article/270757/#. List of controversial changes approved by the APA board for DSM-5, including removal of the bereavement exclusion for major depression.

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Acknowledgments

This paper was supported by grants from the American Foundation for Suicide Prevention, John Majda Foundation, and National Institutes of Health.

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Alana Iglewicz, Kathryn Seay, Samuel David Zetumer, and Sidney Zisook declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Alana Iglewicz.

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Iglewicz, A., Seay, K., Zetumer, S.D. et al. The Removal of the Bereavement Exclusion in the DSM-5: Exploring the Evidence. Curr Psychiatry Rep 15, 413 (2013). https://doi.org/10.1007/s11920-013-0413-0

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