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Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy

  • Food Allergy (T Green, Section Editor)
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Abstract

Food protein-induced enterocolitis (FPIES), allergic proctocolitis (FPIAP), and enteropathy (FPE) are among a number of immune-mediated reactions to food that are thought to occur primarily via non-IgE-mediated pathways. All three are typically present in infancy and are triggered most commonly by cow’s milk protein. The usual presenting features are vomiting with lethargy and dehydration in FPIES; bloody and mucous stools in FPIAP; and diarrhea with malabsorption and failure to thrive in FPE. Diagnosis is based on convincing history and resolution of symptoms with food avoidance; confirmatory diagnostic testing other than food challenge is lacking. The mainstay of management is avoidance of the suspected inciting food, with interval challenge to assess for resolution, which usually occurs in the first years of life. Studies published in the past few years clarify common presenting features, report additional culprit foods, address potential biomarkers, and suggest new management strategies.

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Elizabeth Feuille and Anna Nowak-Węgrzyn have no conflicts of interest.

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  1. Jaffe Food Allergy Institute, Division of Pediatric Allergy, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Elizabeth Feuille & Anna Nowak-Węgrzyn

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Correspondence to Anna Nowak-Węgrzyn.

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Feuille, E., Nowak-Węgrzyn, A. Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy. Curr Allergy Asthma Rep 15, 50 (2015). https://doi.org/10.1007/s11882-015-0546-9

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