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Long-term Results on Weight Loss and Diabetes Remission after Laparoscopic Sleeve Gastrectomy for A Morbidly Obese Chinese Population

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Abstract

Background

Laparoscopic sleeve gastrectomy (LSG) is an effective stand-alone bariatric procedure with favorable short-term results on weight reduction and comorbidity resolution. This study aims to evaluate the long-term results of LSG to see if weight reduction and diabetic improvement are sustainable.

Methods

We conducted a prospective observational study on patients receiving LSG as an index stand-alone bariatric operation in our unit.

Results

Between 2006 and 2014, there were 140 patients (91 females) aged 37.9 ± 10.5 years with a body mass index of 41.0 ± 7.0 kg/m2. At 1-year (n = 123), 2-year (n = 99), 3-year (n = 77), 4-year (n = 52), and 5-year (n = 44) follow-ups, the mean percentages of excess weight loss (%EWL) were 70.5, 65.2, 60.2, 53.2, and 57.2 %, respectively, while the corresponding proportions with failed weight loss (%EWL <30 %) were 7.3, 9.1, 13.0, 25.0, and 22.7 %. Weight regain (>25 % rebound in %EWL) was evident with time as 0, 1.0, 11.6, 19.2, and 29.5 % in the first 5-year follow-ups. In 65 patients with type 2 diabetes mellitus, remission (complete and partial) was achieved in 34.5 % at 1-year, 52.7 % at 3-year, and 70.6 % at 5-year follow-ups. Proportions of patients having optimal glycemic control (HbA1c <7 %) increased significantly from 26.2 % preoperatively to 80.9 % at the first year and maintained at 78.6 % at the fifth year (P < 0.001).

Conclusions

LSG was effective in achieving substantial weight reduction and improved diabetic control for morbidly obese patients. Although weight regain was possible with time, majority of patients could maintain sustainable weight loss, diabetes remission, and glycemic improvement in the long run.

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Conflict of Interest

Dr. Shirley Yuk-Wah Liu, Dr. Simon Kin-Hung Wong, Ms. Candice Chuen-Hing Lam, Ms. Man Yee Yung, Prof. Alice Pik-Shan Kong, and Prof. Enders Kwok-Wai Ng declare that they have no conflict of interest to disclose in this work.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in this study.

Statement of Human Rights

All procedures performed in this study were in accordance with the ethical standards of our institutional research ethics committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Authors and Affiliations

  1. Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong

    Shirley Yuk-Wah Liu, Simon Kin-Hung Wong, Candice Chuen-Hing Lam, Man Yee Yung & Enders Kwok-Wai Ng

  2. Department of Medicine & Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong

    Alice Pik-Shan Kong

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  1. Shirley Yuk-Wah Liu
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  2. Simon Kin-Hung Wong
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  3. Candice Chuen-Hing Lam
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  4. Man Yee Yung
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  6. Enders Kwok-Wai Ng
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Corresponding author

Correspondence to Enders Kwok-Wai Ng.

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Liu, S.YW., Wong, S.KH., Lam, C.CH. et al. Long-term Results on Weight Loss and Diabetes Remission after Laparoscopic Sleeve Gastrectomy for A Morbidly Obese Chinese Population. OBES SURG 25, 1901–1908 (2015). https://doi.org/10.1007/s11695-015-1628-4

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  • DOI: https://doi.org/10.1007/s11695-015-1628-4

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