Skip to main content
Log in

Multiple Inflammatory Myofibroblastic Tumor of the Duodenum: Case Report and Literature Review

  • Case Report
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Inflammatory myofibroblastic tumor (IMT) is a rare low-grade malignant mesenchymal tumor, which can occur at any location, although the lung is the most commonly affected organ. It is extremely rare in the duodenum and only two cases have been reported previously. We report, to our knowledge, the first case of multiple neoplastic lesions.

Case report

A 20-year-old male presented with the chief complaints of intermittent right epigastric pain, nausea and vomiting. Imaging examination, electronic gastroscopy and preoperative biopsy revealed undefined lesions in the duodenum. Pancreaticoduodenectomy was performed and diagnosis of multiple IMT was confirmed by pathological biopsy of the excised tumor. A satisfactory outcome was proved by the follow-up 1 year after curative operation.

Conclusion

IMT can be diagnosed by histological examination and immunohistochemical test after surgical resection. Patients can benefit from radical resection with favorable prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. Coffin CM, Humphrey PA, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Semin Diagn Pathol. 1998 May;15(2):85–101.

    PubMed  CAS  Google Scholar 

  2. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995 Aug;19(8):859–72.

    Article  PubMed  CAS  Google Scholar 

  3. Rabban JT, Zaloudek CJ, Shekitka KM, Tavassoli FA. Inflammatory myofibroblastic tumor of the uterus: a clinicopathologic study of 6 cases emphasizing distinction from aggressive mesenchymal tumors. Am J Surg Pathol. 2005 Oct;29(10):1348–55.

    Article  PubMed  Google Scholar 

  4. Tsuzuki T, Magi-Galluzzi C, Epstein JI. ALK-1 expression in inflammatory myofibroblastic tumor of the urinary bladder. Am J Surg Pathol. 2004 Dec;28(12):1609–14.

    Article  PubMed  Google Scholar 

  5. Wynn GR, Giles A, Steger AS, Wilkinson ML. Case report: inflammatory myofibroblastic tumor of the duodenum. J Gastrointest Cancer. 2008;39(1–4):79–81.

    Article  PubMed  CAS  Google Scholar 

  6. Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Hernández-Nieto E, Leyva-Cobián F, Val-Bernal JF. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol. 2001 May;25(5):624–9.

    Article  PubMed  Google Scholar 

  7. Cassivi SD, Wylam ME. Pulmonary inflammatory myofibroblastic tumor associated with histoplasmosis. Interact Cardiovasc Thorac Surg. 2006 Aug;5(4):514–6.

    Article  PubMed  Google Scholar 

  8. Corapçioğlu F, Kargi A, Olgun N, Ozer E, Olguner M, Sarialioğlu F. Inflammatory myofibroblastic tumor of the ileocecal mesentery mimicking abdominal lymphoma in childhood: report of two cases. Surg Today. 2005;35(8):687–91.

    Article  PubMed  Google Scholar 

  9. Moriyama S, Inayoshi A, Kurano R. Inflammatory pseudotumor of the spleen: report of a case. Surg Today. 2000;30(10):942–6.

    Article  PubMed  CAS  Google Scholar 

  10. Copin MC, Gosselin BH, Ribet ME. Plasma cell granuloma of the lung: difficulties in diagnosis and prognosis. Ann Thorac Surg. 1996 May;61(5):1477–82.

    Article  PubMed  CAS  Google Scholar 

  11. Cerfolio RJ, Allen MS, Nascimento AG, Deschamps C, Trastek VF, Miller DL, Pairolero PC. Inflammatory pseudotumors of the lung. Ann Thorac Surg. 1999 Apr;67(4):933–6.

    Article  PubMed  CAS  Google Scholar 

  12. Gal AA, Koss MN, McCarthy WF, Hochholzer L. Prognostic factors in pulmonary fibrohistiocytic lesions. Cancer. 1994 Apr 1;73(7):1817–24.

    Article  PubMed  CAS  Google Scholar 

  13. Takeda S, Onishi Y, Kawamura T, Maeda H. Clinical spectrum of pulmonary inflammatory myofibroblastic tumor. Interact Cardiovasc Thorac Surg. 2008 Aug;7(4):629–33.

    Article  PubMed  Google Scholar 

  14. Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol. 1991 Dec;15(12):1146–56.

    Article  PubMed  CAS  Google Scholar 

  15. Imabun S, Namba M, Kina M, Uetsu M, Hoshida Y. Inflammatory pseudotumor of the abdomen: report of a case. Surg Today. 1998;28(11):1172–4.

    Article  PubMed  CAS  Google Scholar 

  16. Dishop MK, Warner BW, Dehner LP, Kriss VM, Greenwood MF, Geil JD, Moscow JA. Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy. J Pediatr Hematol Oncol. 2003 Feb;25(2):153–8.

    Article  PubMed  Google Scholar 

  17. Hussain SF, Salahuddin N, Khan A, Memon SS, Fatimi SH, Ahmed R. The insidious onset of dyspnea and right lung collapse in a 35-year-old man. Chest. 2005 May;127(5):1844–7.

    Article  PubMed  Google Scholar 

  18. Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000 Aug;157(2):377–84.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yi Lv.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Xiang, J., Liu, X., Wu, S. et al. Multiple Inflammatory Myofibroblastic Tumor of the Duodenum: Case Report and Literature Review. J Gastrointest Surg 16, 1442–1445 (2012). https://doi.org/10.1007/s11605-012-1883-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-012-1883-9

Keywords

Navigation