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Combining Two Methods of Global Sensitivity Analysis to Investigate MRSA Nasal Carriage Model

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Abstract

We apply two different sensitivity techniques to a model of bacterial colonization of the anterior nares to better understand the dynamics of Staphylococcus aureus nasal carriage. Specifically, we use partial rank correlation coefficients to investigate sensitivity as a function of time and identify a reduced model with fewer than half of the parameters of the full model. The reduced model is used for the calculation of Sobol’ indices to identify interacting parameters by their additional effects indices. Additionally, we found that the model captures an interesting characteristic of the biological phenomenon related to the initial population size of the infection; only two parameters had any significant additional effects, and these parameters have biological evidence suggesting they are connected but not yet completely understood. Sensitivity is often applied to elucidate model robustness, but we show that combining sensitivity measures can lead to synergistic insight into both model and biological structures.

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Acknowledgements

This work was partially funded by CBET 1510743 and CPRIT RR160005.

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Authors and Affiliations

  1. Institute for Computational Engineering and Sciences, University of Texas at Austin, 201 East 24th St, Austin, TX, 78735, USA

    Angela M. Jarrett

  2. Department of Mathematics, Florida State University, 1017 Academic Way, Tallahassee, FL, 32306, USA

    N. G. Cogan & M. Y. Hussaini

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  1. Angela M. Jarrett
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  2. N. G. Cogan
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  3. M. Y. Hussaini
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Correspondence to Angela M. Jarrett.

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Jarrett, A.M., Cogan, N.G. & Hussaini, M.Y. Combining Two Methods of Global Sensitivity Analysis to Investigate MRSA Nasal Carriage Model. Bull Math Biol 79, 2258–2272 (2017). https://doi.org/10.1007/s11538-017-0329-7

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