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A Virtual Culture of CD4+ T Lymphocytes

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Abstract

The CD4+ T cell lineages Th1, Th2, Th17, and Treg, are mammalian cell types that differentiate from the common precursor naive CD4+ T cell. While there is a wealth of experimental data regarding the molecular and cellular signals involved in the differentiation of CD4+ T cells in vitro, there is still no consensus regarding the structure of the network of interactions at the molecular and cellular levels controlling this differentiation process. In this work, a virtual culture of cells is constructed by interconnecting several instances of an updated version of the regulatory network controlling the differentiation process of CD4+ T cells in mice. The virtual culture is a multi-compartment model with an instance of a regulatory network inside each compartment, thus simulating a simplified version of a cell culture in a well-stirred reactor. The virtual culture is able to describe the stable molecular expression patterns described for fully differentiated CD4+ T cells in mice, as well as the differentiation process from a precursor to a given effector cell in response to specific molecular stimuli.

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Acknowledgement

The author wants to acknowledge the invaluable comments and suggestions to improve the present manuscript made by two anonymous referees as well as by the guest editors Dr. Claudine Chaouiya and Dr. Elisabeth Remy.

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  1. Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, México

    Luis Mendoza

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Mendoza, L. A Virtual Culture of CD4+ T Lymphocytes. Bull Math Biol 75, 1012–1029 (2013). https://doi.org/10.1007/s11538-013-9814-9

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