Abstract
The surface protein B7-H1, also called PD-L1 and CD274, is found on carcinomas of the lung, ovary, colon, and melanomas but not on most normal tissues. B7-H1 has been experimentally determined to be an antiapoptotic receptor on cancer cells, where B7-H1-positive cancer cells have been shown to be immune resistant, and in vitro experiments and mouse models have shown that B7-H1-negative tumor cells are significantly more susceptible to being repressed by the immune system. We derive a new mathematical model for studying the interaction between cytotoxic T cells and tumor cells as affected by B7-H1. By integrating experimental data into the model, we isolate the parameters that control the dynamics and obtain insights on the mechanisms that control apoptosis.
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Galante, A., Tamada, K. & Levy, D. B7-H1 and a Mathematical Model for Cytotoxic T Cell and Tumor Cell Interaction. Bull Math Biol 74, 91–102 (2012). https://doi.org/10.1007/s11538-011-9665-1
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DOI: https://doi.org/10.1007/s11538-011-9665-1