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Modelling the Role of Tax Expression in HTLV-I Persistence in vivo

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Abstract

Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease, and adult T-cell leukemia (ATL). Chronically infected individuals often harbor high proviral loads despite maintaining a persistently activated immune response. Based on a new hypothesis for the persistence of HTLV-I infection, a three-dimensional compartmental model is constructed that describes the dynamic interactions among latently infected target cells, target-cell activation, and immune responses to HTLV-I, with an emphasis on understanding the role of Tax expression in the persistence of HTLV-I.

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Authors and Affiliations

  1. Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada

    Michael Y. Li

  2. Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St Giles’, Oxford, OX1 3LB, UK

    Aaron G. Lim

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  1. Michael Y. Li
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  2. Aaron G. Lim
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Correspondence to Aaron G. Lim.

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Li, M.Y., Lim, A.G. Modelling the Role of Tax Expression in HTLV-I Persistence in vivo. Bull Math Biol 73, 3008–3029 (2011). https://doi.org/10.1007/s11538-011-9657-1

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  • DOI: https://doi.org/10.1007/s11538-011-9657-1

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