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A Context-Sensitive Mechanism in Hippocampal CA1 Networks

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Abstract

This paper presents a possible context-sensitive mechanism in a neural network and at single neuron levels based on the experiments of hippocampal CA1 and their theoretical models. First, the spatiotemporal learning rule (STLR, non-Hebbian) and the Hebbian rule (HEBB) are experimentally shown to coexist in dendrite–soma interactions in single hippocampal pyramidal cells of CA1. Second, the functional differences between STLR and HEBB are theoretically shown in pattern separation and pattern completion. Third, the interaction between STLR and HEBB in neural levels is proposed to play an important role in forming a selective context determined by value information, which is related to expected reward and behavioral estimation.

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Authors and Affiliations

  1. Brain Science Institute, Tamagawa University, 6-1-1, Tamagawagakuen, Machida, Tokyo, 194-0041, Japan

    Minoru Tsukada & Yasuhiro Fukushima

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  1. Minoru Tsukada
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  2. Yasuhiro Fukushima
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Correspondence to Minoru Tsukada.

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Tsukada, M., Fukushima, Y. A Context-Sensitive Mechanism in Hippocampal CA1 Networks. Bull Math Biol 73, 417–435 (2011). https://doi.org/10.1007/s11538-010-9566-8

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  • DOI: https://doi.org/10.1007/s11538-010-9566-8

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