Abstract
High-dimensional switches have been proposed as a way to model cellular differentiation, particularly in the context of basic Helix-Loop-Helix (bHLH) competitive heterodimerization networks. A previous study derived a simple rule showing how many elements can be co-expressed, depending on the rate of competition within the network. A limitation to that rule, however, is that many biochemical parameters were considered to be identical. Here, we derive a generalized rule. This in turns allows one to study more ways in which these networks could be regulated, linking intrinsic cellular differentiation determinants to extra-cellular cues.
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Cinquin, O., Page, K.M. Generalized, Switch-Like Competitive Heterodimerization Networks. Bull. Math. Biol. 69, 483–494 (2007). https://doi.org/10.1007/s11538-006-9114-8
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DOI: https://doi.org/10.1007/s11538-006-9114-8