Skip to main content
SpringerLink
Log in

A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging

  • Communications
  • Published:
Science China Chemistry Aims and scope Submit manuscript

Abstract

Osteosarcoma is the most common primary malignant tumor of bone, particularly among children and adolescents. Advances in imaging, surgical techniques, and implants have dramatically reduced the need for amputation in the past three decades. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) shows impressive advantages of deeper tissue penetration and higher spatial resolution, which makes it a promising tool for the early diagnosis and post-operative observation of Osteosarcoma. To the best of our knowledge, this paper is the first time to develop a novel NIR-II fluorescence probe conjugated with an osteosarcoma targeted oligopeptide for molecular tumor imaging in a xenograft orthotopic osteosarcoma mouse model.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Rousseau J, Escriou V, Perrot P, Picarda G, Charrier C, Scherman D, Heymann D, Rédini F, Trichet V. Cancer Gene Ther, 2010, 17: 387–397

    Article  CAS  Google Scholar 

  2. Harrison DJ, Geller DS, Gill JD, Lewis VO, Gorlick R. Expert Rev Anticancer Ther, 2018, 18: 39–50

    Article  CAS  Google Scholar 

  3. Bielack S, Jurgens H, Jundt G, Kevric M, Kuhne T, Reichardt P, Zoubek A, Werner M, Winkelmann W, Kotz R. Cancer Treat Res, 2009, 152: 289–308

    Article  Google Scholar 

  4. Hong G, Antaris AL, Dau H. Nat Biomed Eng, 2017, 1: 0010

    Article  CAS  Google Scholar 

  5. Arndt CAS, Rose PS, Folpe AL, Laack NN. Mayo Clin Proc, 2012, 87: 475–487

    Article  Google Scholar 

  6. Ulaner G, Hwang S, Landa J, Lefkowitz RA, Panicek DM. Int Orthopaedics (SICOT), 2013, 37: 877–882

    Article  Google Scholar 

  7. Tipirneni KE, Rosenthal EL, Moore LS, Haskins AD, Udayakumar N, Jani AH, Carroll WR, Morlandt AB, Bogyo M, Rao J, Warram JM. Mol Imag Biol, 2017, 19: 645–655

    Article  CAS  Google Scholar 

  8. Tang Y, Li Y, Hu X, Zhao H, Ji Y, Chen L, Hu W, Zhang W, Li X, Lu X, Huang W, Fan Q. Adv Mater, 2018, 30: 1801140

    Article  Google Scholar 

  9. Wang Q, Dau Y, Xu J, Cau J, Niu X, Zhang L, Chen R, Shen Q, Huang W, Fan Q. Adv Funct Mater, 2019, 29: 1901480

    Article  Google Scholar 

  10. Yang J, Hong X. Sci China Chem, 2019, 62: 7–8

    Article  CAS  Google Scholar 

  11. Wu X, Shao A, Zhu S, Guo Z, Zhu W. Sci China Chem, 2016, 59: 62–69

    Article  CAS  Google Scholar 

  12. Zhou H, Xiao Y, Hong X. Chin Chem Lett, 2018, 29: 1425–1428

    Article  CAS  Google Scholar 

  13. Huang J, Xie C, Zhang X, Jiang Y, Li J, Fan Q, Pu K. Angew Chem Int Ed, 2019, 58: 15120–15127

    Article  CAS  Google Scholar 

  14. Lin J, Zeng X, Xiao Y, Tang L, Nong J, Liu Y, Zhou H, Ding B, Xu F, Tong H, Deng Z, Hong X. Chem Sci, 2019, 10: 1219–1226

    Article  CAS  Google Scholar 

  15. Zhang H, Fan Y, Pei P, Sun C, Lu L, Zhang F. Angew Chem Int Ed, 2019, 58: 10153–10157

    Article  CAS  Google Scholar 

  16. Sun C, Li B, Zhao M, Wang S, Lei Z, Lu L, Zhang H, Feng L, Dou C, Yin D, Xu H, Cheng Y, Zhang F. J Am Chem Soc, 2019, 141: 19221–19225

    Article  CAS  Google Scholar 

  17. Lei Z, Sun C, Pei P, Wang S, Li D, Zhang X, Zhang F. Angew Chem, 2019, 131: 8250–8255

    Article  Google Scholar 

  18. Wang S, Fan Y, Li D, Sun C, Lei Z, Lu L, Wang T, Zhang F. Nat Commun, 2019, 10: 1058

    Article  Google Scholar 

  19. Hong G, Lee JC, Robinson JT, Raaz U, Xie L, Huang NF, Cooke JP, Dau H. Nat Med, 2012, 18: 1841–1846

    Article  CAS  Google Scholar 

  20. Cosco ED, Caram JR, Bruns OT, Franke D, Day RA, Farr EP, Bawendi MG, Sletten EM. Angew Chem Int Ed, 2017, 56: 13126–13129

    Article  CAS  Google Scholar 

  21. Li C, Zhang Y, Chen G, Hu F, Zhao K, Wang Q. Adv Mater, 2017, 29: 1605754

    Article  Google Scholar 

  22. Hao X, Li C, Zhang Y, Wang H, Chen G, Wang M, Wang Q. Adv Mater, 2018, 30: 1804437

    Article  Google Scholar 

  23. Du Y, Xu B, Fu T, Cau M, Li F, Zhang Y, Wang Q. J Am Chem Soc, 2010, 132: 1470–1471

    Article  CAS  Google Scholar 

  24. Guo Z, Ma Y, Liu Y, Yan C, Shi P, Tian H, Zhu WH. Sci China Chem, 2018, 61: 1293–1300

    Article  CAS  Google Scholar 

  25. Tang Y, Shao A, Cao J, Li H, Li Q, Zeng M, Liu M, Cheng Y, Zhu W. Sci China Chem, 2018, 61: 184–191

    Article  CAS  Google Scholar 

  26. Sheng Z, Guo B, Hu D, Xu S, Wu W, Liew WH, Yao K, Jiang J, Liu C, Zheng H, Liu B. Adv Mater, 2018, 30: 1800766

    Article  Google Scholar 

  27. Antaris AL, Chen H, Cheng K, Sun Y, Hong G, Qu C, Diao S, Deng Z, Hu X, Zhang B, Zhang X, Yaghi OK, Alamparambil ZR, Hong X, Cheng Z, Dau H. Nat Mater, 2016, 15: 235–242

    Article  CAS  Google Scholar 

  28. Zeng X, Xue L, Chen D, Li S, Nong J, Wang B, Tang L, Li Q, Li Y, Deng Z, Hong X, Wu M, Xiao Y. Chem Commun, 2019, 55: 14287–14290

    Article  CAS  Google Scholar 

  29. Ding B, Xiao Y, Zhou H, Zhang X, Qu C, Xu F, Deng Z, Cheng Z, Hong X. J Med Chem, 2019, 62: 2049–2059

    Article  CAS  Google Scholar 

  30. Liu H, Hong G, Luo Z, Chen J, Chang J, Gong M, He H, Yang J, Yuan X, Li L, Mu X, Wang J, Mi W, Luo J, Xie J, Zhang XD. Adv Mater, 2019, 46: 1901015

    Article  Google Scholar 

  31. Shi Y, Yuan W, Liu Q, Kong M, Li Z, Feng W, Hu K, Li F. ACS Mater Lett, 2019, 1: 418–424

    Article  CAS  Google Scholar 

  32. Jia Q, Liu Y, Duan Y, Zhou J. Anal Chem, 2019, 91: 11433–11439

    Article  CAS  Google Scholar 

  33. Meng X, Zhang J, Sun Z, Zhou L, Deng G, Li S, Li W, Gong P, Cau L. Theranostics, 2018, 8: 6025–6034

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (81773674, 21473041, 81573383), Natural Science Foundation of Hubei Province (2017CFB711, 2017CFA024, 2016ACA126), the Fundamental Research Funds for the Central Universities, Tibet Autonomous Region Science and Technology Plan Project Key Project (XZ201901-GB-11), the Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology (2019020701011429), Project First-Class Disciplines Development Supported by Chengdu University of Traditional Chinese Medicine (CZYJC1903), and Health Commission of Hubei Province Scientific Research Project (WJ2019M178, WJ2019M177).

Author information

Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China

    Jiacheng Lin, Qianqian Li, Xiaodong Zeng, Ziyang Chen, Qihang Ding, Yang Li, Hui Zhou, Zixin Deng, Xuechuan Hong & Yuling Xiao

  2. Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Sichuan, 611137, China

    Xianli Meng

  3. Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK

    Jiacheng Lin

  4. Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Jiangxi, 341000, China

    Deliang Chen

Authors
  1. Jiacheng Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qianqian Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiaodong Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ziyang Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Qihang Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hui Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Xianli Meng
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Deliang Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Zixin Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Xuechuan Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Yuling Xiao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuling Xiao.

Additional information

Conflict of interest

The authors declare that they have no conflict of interest.

Supporting information

The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

Supporting Information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, J., Li, Q., Zeng, X. et al. A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging. Sci. China Chem. 63, 766–770 (2020). https://doi.org/10.1007/s11426-019-9685-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11426-019-9685-6

Keywords

Search

Navigation