Abstract
The occurrence, seasonal variation, and environmental impact of five widely used parabens, methyl-(MeP), ethyl-(EtP), n-propyl-(n-PrP), n-butyl-(n-BuP), and benzyl-(BzP) parabens, were investigated in a municipal wastewater treatment plant (WWTP) located in Guangzhou, China, for 1 year. The concentrations of ∑5parabens in the influent and the effluent were 94.2–957 and 0.89–14.7 ng L−1, respectively. The influent paraben concentrations in autumn were significantly lower than in winter, spring, and summer, and the concentrations were generally higher in spring. The removal efficiencies of ∑5parabens in the dissolved phase were over 96%, with high efficiencies in MeP, EtP, and n-PrP. Risk assessment indicated that parabens in the effluent were not likely to pose an environmental risk to aquatic ecosystems. The present study indicates that the treatment processes employed in full-scale WWTPs are effective at removing parabens and highlights the possibility of utilizing WWTPs for restoring water quality in riverine and coastal regions heavily impacted by paraben contamination.
Similar content being viewed by others
References
Bledzka D, Gromadzinska J, Wasowicz W (2014) Parabens. From environmental studies to human health. Environ Int 67:27–42. https://doi.org/10.1016/j.envint.2014.02.007
Cecchi AM, Koskinen WC, Cheng HH, Haider K (2004) Sorption–desorption of phenolic acids as affected by soil properties. Biol Fertil Soils 39:235–242. https://doi.org/10.1007/s00374-003-0710-6
Chen W-L, Ling YS, Lee DJH, Lin X-Q, Chen Z-Y, Liao H-T (2020) Targeted profiling of chlorinated transformation products and the parent micropollutants in the aquatic environment: a comparison between two coastal cities. Chemosphere 242:125268. https://doi.org/10.1016/j.chemosphere.2019.125268
China Food and Drug Administration (2015) Safety and technical standards for cosmetics. (in Chinese)
Dambal VY, Selvan KP, Lite C, Barathi S, Santosh W (2017) Developmental toxicity and induction of vitellogenin in embryo-larval stages of zebrafish (Danio rerio) exposed to methyl Paraben. Ecotoxicol Environ Saf 141:113–118. https://doi.org/10.1016/j.ecoenv.2017.02.048
European Commission (2014) Commission regulation (EU) No 358/2014. Off J Eur Union
Frontistis Z, Antonopoulou M, Venieri D, Dailianis S, Konstantinou I, Mantzavinos D (2017) Solar photocatalytic decomposition of ethyl paraben in zinc oxide suspensions. Catal Today 280:139–148. https://doi.org/10.1016/j.cattod.2016.06.008
González-Mariño I, Quintana JB, Rodríguez I, Cela R (2011) Evaluation of the occurrence and biodegradation of parabens and halogenated by-products in wastewater by accurate-mass liquid chromatography-quadrupole-time-of-flight-mass spectrometry (LC-QTOF-MS). Water Res 45:6770–6780. https://doi.org/10.1016/j.watres.2011.10.027
Guo Y, Wang L, Kannan K (2014) Phthalates and parabens in personal care products from China: concentrations and human exposure. Arch Environ Contam Toxicol 66:113–119. https://doi.org/10.1007/s00244-013-9937-x
Haman C, Dauchy X, Rosin C, Munoz JF (2015) Occurrence, fate and behavior of parabens in aquatic environments: a review. Water Res 68:1–11. https://doi.org/10.1016/j.watres.2014.09.030
Hu P, Chen X, Whitener RJ, Boder ET, Jones JO, Porollo A, Chen J, Zhao L (2013) Effects of parabens on adipocyte differentiation. Toxicol Sci 131:56–70. https://doi.org/10.1093/toxsci/kfs262
Jonkers N, Kohler HP, Dammshauser A, Giger W (2009) Mass flows of endocrine disruptors in the Glatt River during varying weather conditions. Environ Pollut 157:714–723. https://doi.org/10.1016/j.envpol.2008.11.029
Juksu K et al (2019) Occurrence, fate and risk assessment of biocides in wastewater treatment plants and aquatic environments in Thailand. Sci Total Environ 690:1110–1119. https://doi.org/10.1016/j.scitotenv.2019.07.097
Karthikraj R, Vasu AK, Balakrishna K, Sinha RK, Kannan K (2017) Occurrence and fate of parabens and their metabolites in five sewage treatment plants in India. Sci Total Environ 593-594:592–598. https://doi.org/10.1016/j.scitotenv.2017.03.173
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem 391:1293–1308. https://doi.org/10.1007/s00216-008-1854-x
Li W, Shi Y, Gao L, Liu J, Cai Y (2015) Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant. J Hazard Mater 300:29–38. https://doi.org/10.1016/j.jhazmat.2015.06.060
Liao C, Chen L, Kannan K (2013) Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure. Environ Int 57-58:68–74. https://doi.org/10.1016/j.envint.2013.04.001
Liu WR, Yang YY, Liu YS, Zhang LJ, Zhao JL, Zhang QQ, Zhang M, Zhang JN, Jiang YX, Ying GG (2017) Biocides in wastewater treatment plants: Mass balance analysis and pollution load estimation. J Hazard Mater 329:310–320. https://doi.org/10.1016/j.jhazmat.2017.01.057
Lu J, Li H, Tu Y, Yang Z (2018) Biodegradation of four selected parabens with aerobic activated sludge and their transesterification product. Ecotoxicol Environ Saf 156:48–55. https://doi.org/10.1016/j.ecoenv.2018.02.078
Ma WL, Zhao X, Lin ZY, Mohammed MOA, Zhang ZF, Liu LY, Song WW, Li YF (2016) A survey of parabens in commercial pharmaceuticals from China and its implications for human exposure. Environ Int 95:30–35. https://doi.org/10.1016/j.envint.2016.07.013
Ma WL, Zhao X, Zhang ZF, Xu TF, Zhu FJ, Li YF (2018) Concentrations and fate of parabens and their metabolites in two typical wastewater treatment plants in northeastern China. Sci Total Environ 644:754–761. https://doi.org/10.1016/j.scitotenv.2018.06.358
Mailler R et al (2016) Removal of a wide range of emerging pollutants from wastewater treatment plant discharges by micro-grain activated carbon in fluidized bed as tertiary treatment at large pilot scale. Sci Total Environ 542:983–996. https://doi.org/10.1016/j.scitotenv.2015.10.153
Martin J, Santos JL, Aparicio I, Alonso E (2016) Analytical method for biomonitoring of endocrine-disrupting compounds (bisphenol A, parabens, perfluoroalkyl compounds and a brominated flame retardant) in human hair by liquid chromatography-tandem mass spectrometry. Anal Chim Acta 945:95–101. https://doi.org/10.1016/j.aca.2016.10.004
Molins-Delgado D, Díaz-Cruz MS, Barceló D (2016) Ecological risk assessment associated to the removal of endocrine-disrupting parabens and benzophenone-4 in wastewater treatment. J Hazard Mater 310:143–151. https://doi.org/10.1016/j.jhazmat.2016.02.030
National Health and Family Planning Commission of PRC (2014) National Food Safety Standard - standards for uses of food additives (GB 2760-2014). (in Chinese)
Ramaswamy BR, Shanmugam G, Velu G, Rengarajan B, Larsson DG (2011) GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers. J Hazard Mater 186:1586–1593. https://doi.org/10.1016/j.jhazmat.2010.12.037
Ren L et al (2016) Simultaneous determination of urinary parabens, bisphenol A, triclosan, and 8-hydroxy-2’-deoxyguanosine by liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Anal Bioanal Chem 408:2621–2629. https://doi.org/10.1007/s00216-016-9372-8
Smarr MM, Sundaram R, Honda M, Kannan K, Louis GM (2017) Urinary concentrations of parabens and other antimicrobial chemicals and their association with couples’ fecundity. Environ Health Perspect 125:730–736. https://doi.org/10.1289/EHP189
Song H, Alfiya Y, Dubowski Y, Friedler E (2017) Sorption and biodegradation of propylparaben in greywater by aerobic attached-growth biomass. Sci Total Environ 598:925–930. https://doi.org/10.1016/j.scitotenv.2017.04.032
Sun Q, Li M, Ma C, Chen X, Xie X, Yu CP (2016) Seasonal and spatial variations of PPCP occurrence, removal and mass loading in three wastewater treatment plants located in different urbanization areas in Xiamen, China. Environ Pollut 208:371–381. https://doi.org/10.1016/j.envpol.2015.10.003
Terasaki M, Abe R, Makino M, Tatarazako N (2015) Chronic toxicity of parabens and their chlorinated by-products in Ceriodaphnia dubia. Environ Toxicol 30:664–673. https://doi.org/10.1002/tox.21944
Towers CV, Terry PD, Lewis D, Howard B, Chambers W, Armistead C, Weitz B, Porter S, Borman CJ, Kennedy RCM, Chen J (2015) Transplacental passage of antimicrobial paraben preservatives. J Expo Sci Environ Epidemiol 25:604–607. https://doi.org/10.1038/jes.2015.27
Wang W, Kannan K (2016) Fate of parabens and their metabolites in two wastewater treatment plants in New York State, United States. Environ Sci Technol 50:1174–1181. https://doi.org/10.1021/acs.est.5b05516
Wang X-H, Wang X, Huppes G, Heijungs R, Ren N-Q (2015) Environmental implications of increasingly stringent sewage discharge standards in municipal wastewater treatment plants: case study of a cool area of China. J Clean Prod 94:278–283. https://doi.org/10.1016/j.jclepro.2015.02.007
Wu Y, Sun Q, Wang YW, Deng CX, Yu CP (2017) Comparative studies of aerobic and anaerobic biodegradation of methylparaben and propylparaben in activated sludge. Ecotoxicol Environ Saf 138:25–31. https://doi.org/10.1016/j.ecoenv.2016.12.017
Yamaguchi M, Araki D, Kanamori T, Okiyama Y, Seto H, Uda M, Usami M, Yamamoto Y, Masunaga T, Sasa H (2017) Actual consumption amount of personal care products reflecting Japanese cosmetic habits. J Toxicol Sci 42:797–814. https://doi.org/10.2131/jts.42.797
Yamamoto H, Tamura I, Hirata Y, Kato J, Kagota K, Katsuki S, Yamamoto A, Kagami Y, Tatarazako N (2011) Aquatic toxicity and ecological risk assessment of seven parabens: individual and additive approach. Sci Total Environ 410-411:102–111. https://doi.org/10.1016/j.scitotenv.2011.09.040
Yu K, Li B, Zhang T (2012) Direct rapid analysis of multiple PPCPs in municipal wastewater using ultrahigh performance liquid chromatography-tandem mass spectrometry without SPE pre-concentration. Anal Chim Acta 738:59–68. https://doi.org/10.1016/j.aca.2012.05.057
Zeng S, Chen X, Dong X, Liu Y (2017) Efficiency assessment of urban wastewater treatment plants in China: considering greenhouse gas emissions. Resour Conserv Recycl 120:157–165. https://doi.org/10.1016/j.resconrec.2016.12.005
Zhang B, Gao T (2000) An anoxic/anaerobic/aerobic process for the removal of nitrogen and phosphorus from wastewater. J Environ Sci Health A 35:1797–1801. https://doi.org/10.1080/10934520009377075
Zhang M, Wang C, Peng Y, Wang S, Jia F, Zeng W (2016) Organic substrate transformation and sludge characteristics in the integrated anaerobic anoxic oxic–biological contact oxidation (A2/O–BCO) system treating wastewater with low carbon/nitrogen ratio. Chem Eng J 283:47–57. https://doi.org/10.1016/j.cej.2015.04.111
Funding
The project is supported by Guangzhou University’s 2017 training program for young top-notch personnel (BJ201713), National Natural Science Foundation of China (21477100 and 41230639), Strategic Research Grant (7004184), CityU Startup Grant (7200384), MFPRC Grant (9680132), and Guizhou Provincial Department of Education Youth Science and Technology Talents Growth Project (No. KY[2017]300).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Responsible editor: Ester Heath
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
ESM 1
(DOCX 37.3 kb)
Rights and permissions
About this article
Cite this article
Liu, Z., Tam, N.F.Y., Kuo, D.T.F. et al. Removal, seasonal variation, and environmental impact of parabens in a municipal wastewater treatment facility in Guangzhou, China. Environ Sci Pollut Res 27, 28006–28015 (2020). https://doi.org/10.1007/s11356-020-09083-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-020-09083-7