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Assessment of long-term cardiovascular effects of unilateral nephrectomy

  • Nephrology – Original Paper
  • Published:
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Abstract

Purpose

There is conflicting evidence regarding long-term effects of unilateral nephrectomy such as cardiovascular diseases. Excessive increase in blood pressure (BP) during exercise called “hypertensive response to exercise” may be a sign of unborn hypertension and increased cardiovascular risk. Decrease in glomerular filtration rate (GFR) in patients with unilateral nephrectomy may be associated with disturbance of circadian BP changes without affecting the absolute levels of BP. We aimed to investigate the circadian BP changes and hypertensive response to exercise in normotensive patients with preserved renal functions who had undergone unilateral nephrectomy for other causes rather than organ donation.

Methods

This study enrolled 32 patients (mean age 43.4 ± 9.9 years, male 15) with unilateral nephrectomy and 40 healthy controls (mean age 47 ± 6.1 years, male 17). All patients were undergone both office and ambulatory BP measurements and treadmill stress test.

Results

The median time since nephrectomy was 12 (9–22) years in the patient group. The median GFR of the patient group was lower than that of the controls without significance [85.1 (76.0–97.9) vs. 93.2 (84.5–104.9), respectively; p = 0.14]. There was no significant difference between groups in terms of office BP measurements, night time diastolic and systolic BP, mean arterial pressure (MAP), night/day time ratio of MAP in ambulatory BP measurements. The results of treadmill stress tests and hypertensive response to exercise ratios were also similar between the groups.

Conclusion

This study revealed that there was no increase in long-term cardiovascular risks one decade after unilateral nephrectomy based on circadian BP changes and hypertensive response to exercise in normotensive patients.

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Authors’ contributions

All of the authors contributed planning, conducting and reporting of the work. All contributors are responsible for the overall content as guarantors.

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Authors and Affiliations

  1. Department of Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey

    Sultan Ozkurt

  2. Department of Cardiology, Faculty of Medicine, Çorum Hitit University, Çorum, Turkey

    Yusuf Karavelioglu

  3. Department of Cardiology, Hitit University Çorum Training and Research Hospital, Çorum, Turkey

    Macit Kalcik

  4. Department of Biostatistics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey

    Ahmet Musmul

Authors
  1. Sultan Ozkurt
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  2. Yusuf Karavelioglu
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  3. Macit Kalcik
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  4. Ahmet Musmul
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Corresponding author

Correspondence to Sultan Ozkurt.

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Conflict of interest

Sultan Ozkurt, Yusuf Karavelioglu, Macit Kalcik and Ahmet Musmul declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Ozkurt, S., Karavelioglu, Y., Kalcik, M. et al. Assessment of long-term cardiovascular effects of unilateral nephrectomy. Int Urol Nephrol 49, 867–873 (2017). https://doi.org/10.1007/s11255-017-1553-7

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  • DOI: https://doi.org/10.1007/s11255-017-1553-7

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