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Novel Bu4N+Br− catalyzed one-pot multi-component synthesis of 2-amino nicotinonitriles in aqueous medium

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Abstract

An efficient single-pot strategy for 2-amino nicotinonitrile derivatives 5 has been developed by multi-component reaction of arylaldehydes 1, methylketones 2, malononitrile 3, and ammonium acetate 4 using tetrabutyl ammonium bromide as catalyst in aqueous medium.

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Acknowledgments

Authors thank Dr. M. Lakshmikantham, Director, IICT, for her constant encouragement. Authors C. Kurumurthy and R. Naresh Kumar thank CSIR, New Delhi, Govt. of India, for providing senior research fellowships and contingency grant.

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Authors and Affiliations

  1. Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India

    C. Kurumurthy, R. Naresh Kumar, T. Yakaiah, P. Shanthan Rao & B. Narsaiah

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  1. C. Kurumurthy
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  2. R. Naresh Kumar
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  3. T. Yakaiah
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  4. P. Shanthan Rao
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  5. B. Narsaiah
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Correspondence to B. Narsaiah.

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Kurumurthy, C., Naresh Kumar, R., Yakaiah, T. et al. Novel Bu4N+Br− catalyzed one-pot multi-component synthesis of 2-amino nicotinonitriles in aqueous medium. Res Chem Intermed 41, 3193–3199 (2015). https://doi.org/10.1007/s11164-013-1424-5

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  • DOI: https://doi.org/10.1007/s11164-013-1424-5

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