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Disturbance of Metabotropic Glutamate Receptor-Mediated Long-Term Depression (mGlu-LTD) of Excitatory Synaptic Transmission in the Rat Hippocampus After Prenatal Immune Challenge

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Abstract

Maternal immune challenge has proved to induce moderate to severe behavioral disabilities in the offspring. Cognitive/behavioral deficits are supported by changes in synaptic plasticity in different brain areas. We have reported previously that prenatal exposure to bacterial LPS could induce inhibition of hippocampal long-term potentiation (LTP) in the CA1 area of the juvenile/adult male offspring associated with spatial learning inabilities. Nevertheless, deficits in plasticity could be observed at earlier stages as shown by the early loss of long-term depression (LTD) in immature animals. Moreover, aberrant forms of plasticity were also evidenced such as the transient occurrence of LTP instead of LTD in 15–25 day-old animals. This switch from LTD to LTP seemed to involve the activation of metabotropic glutamate receptor subtype 1 and 5 (mGlu1/5). We have thus investigated here whether the long-term depression elicited by the direct activation of these receptors (mGlu-LTD) with a selective agonist was also disturbed after prenatal stress. We find that in prenatally stressed rats, mGlu1/5 stimulation elicits long-term potentiation (mGlu-LTP) independently of N-methyl-d-aspartate receptors. Both mGlu5 and mGlu1 receptors are involved in this switch of plasticity. Moreover, this mGlu-LTP is still observed at later developmental stages than previously reported, i.e. after 25 day-old. In addition, increasing synaptic GABA with tiagabine tends to inhibit mGlu-LTP occurrence. By contrast, long-term depression induced with the activation of CB1 cannabinoid receptor is unaffected by prenatal stress. Therefore, prenatal stress drastically alters mGlu1/5-associated plasticity throughout development. MGlu-mediated plasticity is an interesting parameter to probe the long-lasting deficits reported in this model.

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Authors and Affiliations

  1. UMR5247 Institut des Biomolécules Max Mousseron – University of Montpellier-CNRS-ENSCM, Team ‘Pharmacochemistry of Synaptic transmission and Neuroprotection’, University of Montpellier-Sciences Faculty, Place E Bataillon, 34095, Montpellier Cedex 05, France

    Mélanie Cavalier, Azza Ben Sedrine, Lea Thevenet, Nadine Crouzin, Janique Guiramand, Marie-Céleste de Jésus Ferreira, Catherine Cohen-Solal, Gérard Barbanel & Michel Vignes

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  1. Mélanie Cavalier
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  2. Azza Ben Sedrine
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  3. Lea Thevenet
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  4. Nadine Crouzin
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  5. Janique Guiramand
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  6. Marie-Céleste de Jésus Ferreira
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  7. Catherine Cohen-Solal
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  8. Gérard Barbanel
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  9. Michel Vignes
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Correspondence to Michel Vignes.

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Cavalier, M., Ben Sedrine, A., Thevenet, L. et al. Disturbance of Metabotropic Glutamate Receptor-Mediated Long-Term Depression (mGlu-LTD) of Excitatory Synaptic Transmission in the Rat Hippocampus After Prenatal Immune Challenge. Neurochem Res 44, 609–616 (2019). https://doi.org/10.1007/s11064-018-2476-0

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  • DOI: https://doi.org/10.1007/s11064-018-2476-0

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