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Temperature Dependence of the Sodium Pump is Altered in the Cerebral Cortex of CCK2 Receptor-Deficient Mice

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Abstract

Previously we have shown that the temperature dependence of the sodium pump (Na+,K+-ATPase) is altered under different neuropathological conditions. In this study we compared temperature dependence of the Na+,K+-ATPase in the fronto-parietal cortex of CCK2 receptor-deficient (homo- and heterozygous) and normal (wild-type) mice. The Arrhenius plot for Na+,K+-ATPase from wild-type brain is non-linear with a breakpoint at 20.3 ± 0.4°C. In case of the brain cell membrane of CCK2 receptor-deficient mice (homo- and heterozygous) the breakpoint on Arrhenius plot was detected at 26.0 ± 1.1°C and 25.4 ± 0.4°C, respectively. The shift of the breakpoint on the Arrhenius plot established in CCK2 receptor-deficiency as well as in case of some other pathological conditions confirms that such kind of alteration in the Na+,K+-ATPase temperature dependence is likely related to the homeostatic adjustment of altered function of the sodium pump.

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Acknowledgments

This work was supported by grant No. 8259 from the Estonian Science Foundation, by targeted financing from Ministry of Education and Science of Estonia (SF0180105s08) and by European Union through the European Regional development Fund.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, Tartu University, Ravila 19, Tartu, Estonia

    T. Salum, C. Kairane, R. Mahlapuu & M. Zilmer

  2. Department of Physiology, Faculty Medicine, Tartu University, Tartu, Estonia

    S. Kõks & E. Vasar

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  1. T. Salum
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  2. S. Kõks
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  3. C. Kairane
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  4. R. Mahlapuu
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  5. M. Zilmer
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Correspondence to T. Salum.

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Salum, T., Kõks, S., Kairane, C. et al. Temperature Dependence of the Sodium Pump is Altered in the Cerebral Cortex of CCK2 Receptor-Deficient Mice. Neurochem Res 35, 688–692 (2010). https://doi.org/10.1007/s11064-009-0119-1

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