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A multicenter study of anaplastic oligodendroglioma: the Korean Radiation Oncology Group Study 13–12

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Abstract

Although some existing evidence supports the addition of chemotherapy (CT) to radiation therapy (RT) for anaplastic oligodendroglioma treatment, controversy about both the criteria for suitable candidates and the optimal treatment schedule remains. We reviewed data from 376 newly diagnosed anaplastic oliogodendroglial tumor patients from nine Korean institutes were reviewed from 2000 to 2010. Total tumor removal was performed in 146 patients. More than 85 % of the entire patients received postoperative RT, and 59 % received CT. Approximately 50 % (n = 189) received CT in addition to RT and 9 % (n = 32) received CT only. A multivariate analysis revealed that younger age, frontal lobe location of the tumor, gross total removal, 1p/19q codeletion, and initial RT were associated with longer progression-free and overall survival rates. No difference was observed in outcomes from the treatment that included either temozolomide or PCV (procarbazine, lomustine, and vincristine) in addition to RT regardless of the 1p/19q deletion status. A clear improvement in progression-free and overall survival was observed for RT and combined CT/RT in compared with CT only. Postoperative RT appears to improve survival for entire group thus total removal and 1p/19q codeletion may not be sufficient criteria to omit RT as a treatment option. These results suggest that RT should continue to be offered as the standard treatment option for patients with anaplastic oligodendroglial tumors.

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Acknowledgments

This work is the collaborative effort of The Brain Tumor Committee of the Korean Radiation Oncology Group.

Funding

Korean Radiation Oncology Group and Cancer Control Program from the Korean Ministry of Health & Welfare (#0820010 to Kim IA).

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Dongnam Institute of Radiological & Medical Sciences, Busan, Korea

    Hyun-Cheol Kang

  2. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea

    Tosol Yu, Il Han Kim & In Ah Kim

  3. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Do Hoon Lim

  4. Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Korea

    Woong-Ki Chung

  5. Department of Radiation Oncology, Yonsei Cancer Center, College of Medicine, Yonsei University, Seoul, Korea

    Chang-Ok Suh

  6. Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Byung Ock Choi

  7. Proton Therapy Center, Research Institute Hospital, National Cancer Center, Goyang, Korea

    Kwan Ho Cho

  8. Department of Radiation Oncology, Gangnam Severance Cancer Hospital, Seoul, Korea

    Jae Ho Cho

  9. Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea

    Jin Hee Kim

  10. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Do-Hyun Nam

  11. Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea

    Chul-Kee Park

  12. Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Yong-Kil Hong

  13. Department of Radiation Oncology, Seoul National University Bundang Hospital, 166 Gumiro Seongnamsi Kyeonggido, Seoul, 463-707, Korea

    In Ah Kim

Authors
  1. Hyun-Cheol Kang
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  2. Tosol Yu
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  3. Do Hoon Lim
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  4. Il Han Kim
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  7. Byung Ock Choi
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  8. Kwan Ho Cho
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  9. Jae Ho Cho
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  10. Jin Hee Kim
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  13. Yong-Kil Hong
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  14. In Ah Kim
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Correspondence to In Ah Kim.

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Kang, HC., Yu, T., Lim, D.H. et al. A multicenter study of anaplastic oligodendroglioma: the Korean Radiation Oncology Group Study 13–12. J Neurooncol 125, 207–215 (2015). https://doi.org/10.1007/s11060-015-1902-2

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  • DOI: https://doi.org/10.1007/s11060-015-1902-2

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