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Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma

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Abstract

Bordetella bronchiseptica is a gram negative coccobacillus that can be transmitted from domestic animals and cause severe infections in immunocompromised patients. A 56-year-old man with a left parietal glioblastoma was treated with resection, radiation and concomitant and adjuvant temozolomide chemotherapy. He received bevacizumab for progression, and dose dense metronomic temozolomide was added for additional progression. He developed chronic cough and was diagnosed with B. bronchiseptica infection. This is the first reported case of B. bronchiseptica infection in a patient receiving temozolomide. The infection was likely acquired from an infected kitten. Patients receiving temozolomide should be counseled on the risks of acquiring zoonotic infections, including B. bronchiseptica, from their pets.

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Author notes

  1. Christian Grommes

    Present address: University Hospitals Case Medical Center, Cleveland, OH, USA

Authors and Affiliations

  1. Department of Medicine, Infectious Disease, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Gil Redelman-Sidi & Genovefa Papanicolaou

  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Christian Grommes

Authors
  1. Gil Redelman-Sidi
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  2. Christian Grommes
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Correspondence to Gil Redelman-Sidi.

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Redelman-Sidi, G., Grommes, C. & Papanicolaou, G. Kitten-transmitted Bordetella bronchiseptica infection in a patient receiving temozolomide for glioblastoma. J Neurooncol 102, 335–339 (2011). https://doi.org/10.1007/s11060-010-0322-6

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  • DOI: https://doi.org/10.1007/s11060-010-0322-6

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