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Cholic Acid-Functionalized Mesoporous Silica Nanoparticles Loaded With Ruthenium Pro-drug Delivery to Cervical Cancer Therapy

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Abstract

Effective delivery of therapeutic molecules by proper surface-modified nanomaterial can disallow the progression of cancer. We report an effective treatment approach based on targeted delivery of ruthenium pro-drug (Ru) by poly ethylamine (PEI) coated ZnO–SiO2 core–shell nanoparticle for encapsulating large quantity of Ru pro-drug and subsequently grafted with functionalized with cholic acid (CA) as a tumor-specific moiety. An elaborate mechanism of core–shell formation and the size, composition, and morphology were characterized with diverse physiochemical studies such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FT-IR). Further, the anti-tumor activity of CA–Ru–PEI–ZnO–SiO2 nanoparticle was confirmed by in vitro studies. The synthesized CA–Ru–PEI–ZnO–SiO2 has a wide core with thicker outer shell showed excellent biocompatibility and a high potential for loading Ru pro-drug for anti-cancer therapy.

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Acknowledgements

The authors are thankful to the College of Clinical Medicine, Yangzhou University, China for availing the needed laboratory and instrument facilities.

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  1. College of Clinical Medicine, Yangzhou University, Yangzhou City, 225002, Jiangsu Province, China

    Wenxin Zhou

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  1. Wenxin Zhou
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Zhou, W. Cholic Acid-Functionalized Mesoporous Silica Nanoparticles Loaded With Ruthenium Pro-drug Delivery to Cervical Cancer Therapy. J Inorg Organomet Polym 31, 311–318 (2021). https://doi.org/10.1007/s10904-020-01710-7

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  • DOI: https://doi.org/10.1007/s10904-020-01710-7

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