Skip to main content
Log in

Lifestyle Risk Factors Among People Who Have Had Cancer Genetic Testing

  • Original Research
  • Published:
Journal of Genetic Counseling

Abstract

Hereditary cancer genetic counseling often focuses on medically intensive risk-reduction strategies, like imaging and risk-reducing surgeries. Lifestyle factors also influence cancer risk, but health behavior counseling is not common in genetic counseling. Information about typical lifestyle risk factors among patients seeking hereditary cancer risk is sparse. The current study describes cancer risk-relevant lifestyle factors for people who have had cancer genetic testing. Data came from the Health Information National Trends Survey (HINTS 4) collected in 2013. Analytic variables represented American Cancer Society nutrition and physical activity guidelines. Lifestyle factors were assessed for people who had undergone testing for BRCA1, BRCA2, or Lynch Syndrome genes. Among 3016 HINTS respondents, 135 had cancer genetic testing. Of these, 58 % were overweight or obese. Eighteen percent reported no moderate-intensity physical activity. Average sedentary screen-time was 3.4 h (SE = 0.472) daily. Sixty-three percent drank non-diet soda, and 23 % of these people drank soda every day. Between 18 and 36 % consumed less than 2 ½ cups fruits/vegetables daily. Twenty-four percent were current smokers. Lifestyle risk factors were not different between people who had genetic testing and those who had not. In conclusion, most people who had genetic testing for cancer susceptibility have at least one modifiable risk factor. Genetic counselors have opportunities to impact a counselee’s cancer risk not only through risk-tailored medical procedures, but also through lifestyle modification recommendations. Results of the current study may foster a broader discussion of genetic counselors’ roles in healthy lifestyle education.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Albada, A., Vernooij, M., van Osch, L., Pijpe, A., van Dulmen, S., & Ausems, M. G. (2014). Does and should breast cancer genetic counselling include lifestyle advice? Familial Cancer, 13(1), 35–44.

    Article  PubMed  Google Scholar 

  • American Cancer Society. (2015). ACS guidelines on nutrition and physical activity for cancer prevention. Retrieved 07/30, 2015, from http://www.cancer.org/healthy/eathealthygetactive/acsguidelinesonnutritionphysicalactivityforcancerprevention/nupa-guidelines-toc.

  • American Institute for Cancer Research. (2015). Recommendations for cancer prevention. Retrieved 07/30, 2015, from http://www.aicr.org/reduce-your-cancer-risk/recommendations-for-cancer-prevention/.

  • Burton, A. M., Peterson, S. K., Marani, S. K., Vernon, S. W., Amos, C. I., Frazier, M. L., et al. (2010). Health and lifestyle behaviors among persons at risk of Lynch syndrome. Cancer Causes & Control: CCC, 21(4), 513–521.

    Article  PubMed  Google Scholar 

  • Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. The New England Journal of Medicine, 348(17), 1625–1638.

    Article  PubMed  Google Scholar 

  • Cragun, D., Camperlengo, L., Robinson, E., Caldwell, M., Kim, J., Phelan, C., et al. (2015). Differences in BRCA counseling and testing practices based on ordering provider type. Genetics in Medicine: Official Journal of the American College of Medical Genetics, 17(1), 51–57.

    Article  CAS  Google Scholar 

  • Daly, M. (2014). Breast cancer risk counseling: A teachable moment? Journal of the National Comprehensive Cancer Network: JNCCN, 12(10), 1361–1362.

    PubMed  Google Scholar 

  • Diergaarde, B., Braam, H., Vasen, H. F., Nagengast, F. M., van Muijen, G. N., Kok, F. J., et al. (2007). Environmental factors and colorectal tumor risk in individuals with Hereditary Nonpolyposis Colorectal Cancer. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 5(6), 736–742.

    Article  Google Scholar 

  • Dorval, M., Bouchard, K., Maunsell, E., Plante, M., Chiquette, J., Camden, S., et al. (2008). Health behaviors and psychological distress in women initiating BRCA1/2 genetic testing: Comparison with control population. Journal of Genetic Counseling, 17(4), 314–326.

    Article  PubMed  Google Scholar 

  • Emmons, K. M., Kalkbrenner, K. J., Klar, N., Light, T., Schneider, K. A., & Garber, J. E. (2000). Behavioral risk factors among women presenting for genetic testing. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 9(1), 89–94.

    CAS  Google Scholar 

  • Hall, M. J., & Olopade, O. I. (2006). Disparities in genetic testing: thinking outside the BRCA box. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 24(14), 2197–2203.

    Article  Google Scholar 

  • King, M. C., Marks, J. H., Mandell, J. B., & New York Breast Cancer Study Group (2003). Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science, 302(5645), 643–646.

    Article  CAS  PubMed  Google Scholar 

  • Lynch, B. M. (2010). Sedentary behavior and cancer: A systematic review of the literature and proposed biological mechanisms. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 19(11), 2691–2709.

    Article  Google Scholar 

  • Mai, P. L., Vadaparampil, S. T., Breen, N., McNeel, T. S., Wideroff, L., & Graubard, B. I. (2014). Awareness of cancer susceptibility genetic testing: the 2000, 2005, and 2010 National Health Interview Surveys. American Journal of Preventive Medicine, 46(5), 440–448.

    Article  PubMed  PubMed Central  Google Scholar 

  • National Society of Genetic Counselors. (2005). Model legislative provisions: Genetic counselor scope of practice. Retrieved 8/2015, 2015, from http://nsgc.org/p/cm/ld/fid=18#scope.

  • Ogden, C. L., Carroll, M. D., & Flegal, K. M. (2014). Prevalence of obesity in the United States. JAMA, 312(2), 189–190.

    Article  CAS  PubMed  Google Scholar 

  • Pijpe, A., Manders, P., Brohet, R. M., Collee, J. M., Verhoef, S., Vasen, H. F., et al. (2010). Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Research and Treatment, 120(1), 235–244.

    Article  PubMed  Google Scholar 

  • Rees, G., Young, M. A., Gaff, C., & Martin, P. R. (2006). A qualitative study of health professionals’ views regarding provision of information about health-protective behaviors during genetic consultation for breast cancer. Journal of Genetic Counseling, 15(2), 95–104.

    Article  PubMed  Google Scholar 

  • Resnicow, K., & McMaster, F. (2012). Motivational Interviewing: moving from why to how with autonomy support. The International Journal of Behavioral Nutrition and Physical Activity, 9, 19.

    Article  PubMed  PubMed Central  Google Scholar 

  • Riley, B. D., Culver, J. O., Skrzynia, C., Senter, L. A., Peters, J. A., Costalas, J. W., et al. (2012). Essential elements of genetic cancer risk assessment, counseling, and testing: Updated recommendations of the National Society of Genetic Counselors. Journal of Genetic Counseling, 21(2), 151–161.

    Article  PubMed  Google Scholar 

  • Schmid, D., & Leitzmann, M. F. (2014). Television viewing and time spent sedentary in relation to cancer risk: a meta-analysis. Journal of the National Cancer Institute, 106(7). doi:10.1093/jnci/dju098 Print 2014 Jul.

  • Shen, D., Mao, W., Liu, T., Lin, Q., Lu, X., Wang, Q., et al. (2014). Sedentary behavior and incident cancer: A meta-analysis of prospective studies. PloS One, 9(8), e105709.

    Article  PubMed  PubMed Central  Google Scholar 

  • Thomson, C. A., McCullough, M. L., Wertheim, B. C., Chlebowski, R. T., Martinez, M. E., Stefanick, M. L., et al. (2014). Nutrition and physical activity cancer prevention guidelines, cancer risk, and mortality in the Women's Health Initiative. Cancer Prevention Research (Philadelphia, Pa.), 7(1), 42–53.

    Article  Google Scholar 

  • U.S. Department of Health and Human Services (2014). The health consequences of smoking: 50 years of progress. A report of the surgeon general. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health.

    Google Scholar 

  • Vadaparampil, S. T., Scherr, C. L., Cragun, D., Malo, T. L., & Pal, T. (2015). Pre-test genetic counseling services for Hereditary Breast and Ovarian Cancer delivered by non-genetics professionals in the state of Florida. Clinical Genetics, 87(5), 473–477.

    Article  CAS  PubMed  Google Scholar 

  • Wang, C., Miller, S. M., Egleston, B. L., Hay, J. L., & Weinberg, D. S. (2010). Beliefs about the causes of breast and colorectal cancer among women in the general population. Cancer Causes & Control: CCC, 21(1), 99–107.

    Article  PubMed  Google Scholar 

  • Watson, P., Ashwathnarayan, R., Lynch, H. T., & Roy, H. K. (2004). Tobacco use and increased colorectal cancer risk in patients with Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome). Archives of Internal Medicine, 164(22), 2429–2431.

    Article  PubMed  Google Scholar 

  • Weil, J., Ormond, K., Peters, J., Peters, K., Biesecker, B. B., & LeRoy, B. (2006). The relationship of nondirectiveness to genetic counseling: Report of a workshop at the 2003 NSGC annual education conference. Journal of Genetic Counseling, 15(2), 85–93.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John M. Quillin.

Ethics declarations

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000.

Conflict of Interest

John Quillin declares he has no conflict of interest.

Human Studies and Informed Consent

No human studies were carried out by the author for this article.

Animal Studies

No animal studies were carried out by the author for this article.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Quillin, J.M. Lifestyle Risk Factors Among People Who Have Had Cancer Genetic Testing. J Genet Counsel 25, 957–964 (2016). https://doi.org/10.1007/s10897-015-9925-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10897-015-9925-6

Keywords

Navigation