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Phenoidentical HLA-Related Hematopoietic Stem Cell Transplant Without Conditioning to Reconstitute a Patient with a Putative Loss-of-Function CARD11 Mutation

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Acknowledgments

The authors thank the patient and his family for their trust and cooperation, as well as the nurses and clinicians at KFSH&RC for their care. Molecular genetic studies were supported by the National Science, Technology and InnovationPlan program in the Kingdom of Saudi Arabia (KACST: 13BIO755-20).

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Authors and Affiliations

  1. Pediatric Allergy & Clinical Immunology, Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, MBC 58, P.O.Box 3354, Riyadh, 11211, Saudi Arabia

    Bashayer Al-Rasheed & Hamoud Al-Mousa

  2. Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    Anas M. Alazami

  3. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia

    Hamoud Al-Mousa

Authors
  1. Bashayer Al-Rasheed
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  2. Anas M. Alazami
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  3. Hamoud Al-Mousa
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Corresponding author

Correspondence to Hamoud Al-Mousa.

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The authors declared that they have no conflict of interest.

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Capsule Summary

Homozygous loss-of-function mutations in CARD11 cause combined immunodeficiency that can be cured with hematopoietic stem cell transplantation from an HLA-matched related donor without conditioning

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Al-Rasheed, B., Alazami, A.M. & Al-Mousa, H. Phenoidentical HLA-Related Hematopoietic Stem Cell Transplant Without Conditioning to Reconstitute a Patient with a Putative Loss-of-Function CARD11 Mutation. J Clin Immunol 40, 1163–1165 (2020). https://doi.org/10.1007/s10875-020-00846-y

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  • DOI: https://doi.org/10.1007/s10875-020-00846-y

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