Abstract
The aim of this study was to investigate the effect of high-intensity swimming exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to the ears. After HISE for 4 weeks, epidermal thickness, mast cell infiltration, serum immunoglobulin E (IgE), and histamine were measured. In addition, the gene expression of interleukin (IL)-5 and IL-31 in the ears was assayed. HISE increased DFE/CDNB-induced AD symptoms based on ear thickness, histopathological analysis, and serum IgE level. Moreover, HISE exercise stimulated mast cell infiltration into the ear, elevation of serum histamine, and DFE/CDNB-induced expression of IL-5 and IL-31 in the ears in the AD model. Taken together, our results indicate the possibility that HISE-induced stress gives rise to AD symptoms through the stimulation of IgE level by increasing IL-5 and IL-31 production.
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ACKNOWLEDGMENTS
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2012S1A5A8024395) and by the “Cooperative Research Program for Agriculture Science & Technology Development (Project No. 009773)” Rural Development Administration, Republic of Korea.
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Sang-Hyun Kim and Eun-Kyung Kim contributed equally to this work.
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Kim, SH., Kim, EK. & Choi, EJ. High-Intensity Swimming Exercise Increases Dust Mite Extract and 1-Chloro-2,4-Dinitrobenzene-Derived Atopic Dermatitis in BALB/c Mice. Inflammation 37, 1179–1185 (2014). https://doi.org/10.1007/s10753-014-9843-z
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DOI: https://doi.org/10.1007/s10753-014-9843-z